Background. The analgesic effects of morphine are delayed relative to its concentration in
blood. The rate of equilibration of morphine between blood and brain may contribute to this …

In a crossover design study we have measured the total body and regional clearances of
morphine. Thirteen experiments were performed in four conscious sheep that had been …

Background. The factors affecting the concentrations of fentanyl in the brain after
intravenous administration have not been completely quantified. Methods. A model …

This study documents the changes in selected regional hemodynamics occurring in
response to large doses of intravenous morphine. It was performed in normal conscious …

Background: During pathologic conditions such as meningitis and traumatic brain injury the
function of the blood–brain barrier (BBB) is disturbed. In the present study we examined the …

The aim of this study was to characterize the reversible cerebral uptake of morphine in the
pig by measuring the changing arterio-venous plasma concentration gradient over the brain …

Abstract Background: A 26-year-old, 59 kg female was administered morphine 10 mg during
tonsillectomy, and 5 mg in the recovery room. She died 5 hours after the operation. Hypoxic …

This study determined the disposition of morphine in plasma and cerebrospinal fluid (CSF)
and its relationship to ventilatory depression." C-Morphine sulfate (0.3 mg/kg or 2.0 mg/kg as …

We determined the magnitude and duration of the effect of morphine (1.0 mg/kg intravenous
bolus) on isoflurane and halothane minimum alveolar concentration (MAC) in six dogs …

A 26-year-old female was treated with morphine within the first 2 hours after knee surgery, in
an attempt to titrate analgesia. The patient received a total of four intravenous injections of …