BACKGROUND: There are two recognized methods of estimating the brain concentrations
of IV anesthetic drugs:(i) use of pharmacokinetic/pharmacodynamic (PK/PD) modeling of …

The relationship between the plasma concentration of morphine and morphine-induced
changes in ventilation and the ventilatory response to carbon dioxide was studied in 17 …

In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC
(minimal alveolar concentration) produced by 2 mg‐kg‐1 morphine intravenously (i‐v.) and …

The effect of chronic renal failure (RF) on the pharmacokinetics of morphine was studied in
nine patients with end-stage RF, aged 58+/-8 yr (SD), and in seven control patients, aged …

We describe a six-compartment kinetic and dynamic physiological model of induction of
anaesthesia with thiopental. The model included an accurate account of initial drug …

Study Objective: To study the pharmacokinetic parameters of morphine and lidocaine after a
single intravenous (IV) bolus in severe trauma patients. Design: Clinical case study. Setting …

A morphine plasma concentration/respiratory rate relationship has been described for both
adults and children although that of its metabolite, morphine-6-glucuronide, remains …

Morphine is used as an anesthetic supplement. Its disposition in surgical patients under
enflurane-nitrous oxide anesthesia has not been determined. Available data on morphine …

We describe a six-compartment physiological model of the kinetics and dynamics of
induction of anaesthesia with propofol in sheep. It includes a faithful description of initial …

Eleven baboons, anaesthetised with ketamine, had catheters introduced into the cisterna
magna. Morphine was injected at lumbar level intrathecally in six and epidurally in five …