Background Context-sensitive times to 50%, 80%, and 90% elimination from the brain have
been calculated for volatile anaesthetics. This does not represent complete recovery …

The morphine concentration in serum as well as in cerebrospinal fluid (CSF) after epidural
administration of 0.1 mg/kg morphine to 10 patients undergoing aortic abdominal surgery …

BACKGROUND: Despite widespread use of chronic intrathecal (IT) infusions of morphine,
there is little systematic human work evaluating the steady state morphine concentrations or …

The opioid system, composed of a family of structurally related endogenous peptides acting
at µ-, δ-and κ-opioid receptors,(µOR, δOR and κOR, is involved in responses to pain, stress …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• It has been recognized for about 10
years that morphine is a veno‐dilator in man and that this effect may be related to histamine …

The concentration of morphine and morphine glucuronide in serum after epidural injection of
9 patients with aortic abdominal surgery was measured using gas chromatography-mass …

Loading and maintenance infusions of morphine sulfate were administered to 5 young male
patients 23-34-yr-old prior to elective surgery. Apparent steady-state plasma concentrations …

Morphine is a widely used analgesic for treatment of acute and chronic pain. The use of
intravenous morphine-particularly in combination with muscle relaxants, nitrous oxide, and …

Objective: To evaluate the pharmacokinetic parameters of morphine and lidocaine after a
single intravenous dose in critically ill patients. Design: Prospective, clinical study. Setting …

The pharmacokinetics of morphine were studied in various tissues of rats subjected to a
single dose treatment (SDT, 30 mg/kg), constant dose treatment (CDT, 30 mg/kg daily for 8 …