Background The rate of onset of drug actions in experiments with brain slices in vitro can
vary widely. One factor that influences the rate is access to tissue sites of action. To study the …

Objective To evaluate histamine release and selected physiologic variables during constant
rate infusion (CRI) of morphine in dogs. Animals Five healthy, conscious, intact female dogs …

Tritium-labeled morphine was injected into the lumbar (L4—5) subarachnoid space of three
baboons. The animals were sacrificed 3, 6, and 24 hr thereafter. Morphine concentrations …

The effect of doses of morphine (10 mg/70 kg) on the forearm blood flow and vascular
resistance was evaluated in 10 adults. The present findings were correlated with the central …

The influence of anaesthesia and surgery on the pharmacokinetics of morphine was studied
in 10 patients. Plasma concentrations of morphine were assayed by gas chromatography …

Because morphine is used worldwide as the potent standard analgesic drug, with the
formation of an even more potent metabolite M6G, it is important to elucidate the relative …

We have evaluated the effects of lumbar extradural morphine and lignocaine on the
ventilatory response to carbon dioxide. Twenty-four female patients were allocated randomly …

After intravenous administration of an analgesic dose of morphine into rat, the time course of
morphine concentrations was followed in plasma, whole brain, and four discrete areas of the …

To gain insights into the working mechanism of morphine, regional cerebral blood flow
(rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross …

The effects of epidural morphine (50 micrograms X kg-1) after abdominal and urologic
surgery were studied in 20 children ranging in age from 2 to 15 yr and weighing between 9 …