Based on volume-flow relationships, CNS agents that are highly lipid soluble (log octanol-
water partition coefficient> 2) are expected to have equilibration half-times (T1/2 kE0) that …

Clinical experience and laboratory studies suggest that neonates are more sensitive than
adults to the ventilatory depressant effects of morphine. Similar sensitivity has been cited …

The kinetics of “C–labelled morphine and pethidine were studied by positron emission
tomography (PET) at different levels of the spinal canal (C4, T4, T5, T6, LI and L6). Studies …

Ten healthy volunteers were given an iv infusion of 10 mg morphine HC1, an oral solution of
20 mg morphine HC1, or a new controlled release tablet of 30 mg morphine sulphate on …

Morphine, pethidine and fentanyl have similar pharmacokinetic profiles with moderately long
elimination half-lives (3 to 4 hours), large steady-state volumes of distribution (2 to 4 l/kg) …

We present a physiologically stable porcine model designed for sequential assessments of
pharmacological effects on mean hemispheric cerebral blood flow (CBF) and cerebral …

The cerebral and systemic kinetics of intravenous thiopentone (250 mg over 2 minutes, n= 5)
and propofol (100 mg over 2 minutes, n= 6) were determined in sheep anaesthetized with …

Oxycodone is an opioid analgesic that is administered orally or parenterally. The time-
course of opioid action is a function of the systemic kinetics of the opioid, and the rate and …

Aims Concentrations in the cerebrospinal fluid (CSF) are a useful approximation to the effect
site for drugs like morphine. However, CSF samples, are available only in rare …

BACKGROUND: In pharmacokinetic–pharmacodynamic modeling studies, venous plasma
samples are sometimes used to derive pharmacodynamic model parameters. In the current …