Background The influence of changes in the physiologic state of a patient on the disposition
of fentanyl and alfentanil is poorly understood. The aims of this study were to determine …

The steady-state tissue/blood partition coefficients of fentanyl and alfentanil were
determined in 13 organs and tissues in the rat. A 6-h infusion of both drugs was used in …

The objectives of this investigation were to characterize the disposition of fentanyl and
alfentanil in 14 tissues in the rat, and to create physiological pharmacokinetic models for …

Traditionally, physiological pharmacokinetic models assume that arterial blood flow to tissue
is the rate-limiting step in the transfer of drug into tissue parenchyma. When this assumption …

A variable rate infusion regimen, designed to rapidly achieve and maintain a target arterial
concentration (CT) of 100 [mu] g [middle dot] L-1 of alfentanil, was developed using the …

A major reason for quantitating the relationship of drug dose to plasma concentration is to
design optimal drug administration schemes (ie, those that can achieve desired target …

To achieve therapeutic plasma concentrations of the opioid alfentanil, one must administer
the drug as a variable rate continuous infusion. For most patients, using population …

The derived pharmacokinetic data for the intravenous administration of fentanyl obtained
from seven previous studies were compared using computer simulation of predicted plasma …

Background The currently available pharmacokinetic models for fentanyl were derived from
normal weight patients and were not scaled to body weight. Their application to obese …

Fentanyl is used as an analgesic in small doses (1-2 micrograms X kg-1) and as an
anesthetic in very large doses (greater than 150 micrograms X kg-1). It has been …