Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain
degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical …

Objectives Amyotrophic lateral sclerosis (ALS) is a fatal disease characterised by combined
upper and lower motor neuron degeneration. An early and accurate diagnosis is important …

The aim of this study was to investigate the extent of cortical and subcortical lesions in
amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor …

We investigated whether conventional and diffusion tensor (DT) magnetic resonance
imaging (MRI) features of the corticospinal tract (CST) contribute to the prediction of the long …

Background and aims Considering the great heterogeneity of amyotrophic lateral sclerosis
(ALS), the identification of accurate prognostic predictors is fundamental for both the clinical …

Objective To discern presymptomatic changes in brain structure or function using advanced
MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). Methods T1 …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

ObjectiveAdvanced neuroimaging techniques may offer the potential to monitor disease
progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative, multisystem …

BACKGROUND AND PURPOSE: Recent evidence from neuropsychologic and
neuroimaging studies suggests that central nervous system involvement in amyotrophic …

Purpose To study the relative contributions of brain and upper cervical spinal cord
compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (ALS) …