Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?

E Finegan, RH Chipika, SLH Shing… - … Lateral Sclerosis and …, 2019 - Taylor & Francis
Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Primary lateral sclerosis: A heterogeneous disorder composed of different subtypes?

P Zhai, F Pagan, J Statland, JA Butman, MK Floeter - Neurology, 2003 - AAN Enterprises
Objective: To determine identifiable subgroups of patients with primary lateral sclerosis
(PLS) with distinct clinical features as a first step in identifying patients likely to have the …

Demographics and clinical characteristics of primary lateral sclerosis: case series and a review of literature

RS Ramanathan, S Rana - Neurodegenerative Disease …, 2018 - Future Medicine
Aim: Primary lateral sclerosis (PLS) is a form of motor neuron disease involving only upper
motor neurons. In some patients presenting as PLS, the disease progresses to involve lower …

What is primary lateral sclerosis?

M Swash, J Desai, VP Misra - Journal of the neurological sciences, 1999 - Elsevier
Primary lateral sclerosis (PLS) is a rare degenerative disorder of the upper motor neuron. Its
nosological status and relationship to other motor neuron syndromes, especially …

The concept and diagnostic criteria of primary lateral sclerosis

V Wais, A Rosenbohm, S Petri… - Acta Neurologica …, 2017 - Wiley Online Library
Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

Primary lateral sclerosis: further clarification

N Le Forestier, T Maisonobe, L Spelle, A Lesort… - Journal of the …, 2001 - Elsevier
Primary lateral sclerosis (PLS) has been defined as a rare. Non-hereditary disease
characterized by progressive spinobulbar spasticity, related to the exclusive involvement of …

A case series of PLS patients with frontotemporal dementia and overview of the literature

BS de Vries, LMM Rustemeijer… - … Lateral Sclerosis and …, 2017 - Taylor & Francis
Objective: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease
characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a …

Primary lateral sclerosis: the era of international diagnosis criteria

N Le Forestier, V Meininger - Revue Neurologique, 2008 - europepmc.org
[Primary lateral sclerosis: the era of international diagnosis criteria]. - Abstract - Europe PMC Sign
in | Create an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact …

Neuropathology of primary lateral sclerosis

IRA Mackenzie - Amyotrophic Lateral Sclerosis and …, 2020 - Taylor & Francis
Published descriptions of the neuropathology of clinically defined primary lateral sclerosis
(PLS) are reviewed in order to clarify the pathogenesis and the relationship between PLS …

Natural history of “pure” primary lateral sclerosis

A Hassan, SO Mittal, WT Hu, KA Josephs… - Neurology, 2021 - AAN Enterprises
Objective To assess whether primary lateral sclerosis (PLS), classified as pure when the
EMG is normal, converts to amyotrophic lateral sclerosis (ALS) after longitudinal follow-up …