In our preliminary study, the urinary excretion of morphinone as a new metabolite of
morphine in guinea pigs has been confirmed by isolations of the metabolite as 8-(2 …

A New Metabolic Pathway of Morphine: In Vivo and In Vitro Formation of Morphinone and
Morphinone-Glutathione Adduct in Guinea Pi Page 1 VoL 255, No.2 Printed in US.A …

Morphine is a potent analgesic and is widely used in the clinical management of severe
acute and chronic pain; however, its clinical usefulness is limited due to the development of …

Techniques based on thin-layer chromatography were applied qualitatively in an
investigation into the metabolism of morphine in rats. The isolation of dihydromorphinone as …

1. Morphinone, a toxic metabolite, and its glutathione adduct (MO-GSH) were identified in
the bile of rat after subcutaneous injection of morphine (25 mg/kg) by hplc procedures. The …

A rapid and simple method for the determination of morphine (M), normorphine (NM),
morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) in plasma by high …

A high-performance liquid chromatography tandem mass spectrometry-mass spectrometry
(LC-MS-MS) assay was developed for the analyses of morphine, morphine glucuronides …

Morphinone, identified in the bile of guinea pigs and rats given morphine, is a reactive
electrophile and has the ability to bind to glutathione (GSH) and tissue macromolecules …

A rapid, highly sensitive method for the determination of morphine and its metabolites
morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and normorphine has been …

Biotransformation of morphine to dihydromorphinone and normorphine was studied in
several mammalian species. Free and total dihydromophinone, morphine, and normorphine …