[HTML][HTML] Central nervous system distribution of buprenorphine in pregnant sheep, fetuses and newborn lambs after continuous transdermal and single subcutaneous …

H Hakomäki, S Eskola, H Kokki, M Lehtonen… - European Journal of …, 2022 - Elsevier
Buprenorphine is used during pregnancy for the treatment of opioid use disorder. Limited
data exist on the central nervous system (CNS) permeation and distribution, and on the fetal …

[HTML][HTML] Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: buprenorphine pharmacokinetics in pregnant sheep

H Hakomäki, H Kokki, M Lehtonen, J Räsänen… - European Journal of …, 2021 - Elsevier
Background Buprenorphine is used in the opioid maintenance treatment for opioid
dependent patients, including pregnant women. Despite the wide use, limited data exists on …

Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection

H Hakomäki, H Kokki, M Lehtonen… - Pharmacology …, 2021 - Wiley Online Library
Buprenorphine is a semi‐synthetic opioid, widely used in the maintenance treatment for
opioid‐dependent pregnant women. Limited data exist on the pharmacokinetics of …

Dose-adjusted plasma concentrations of sublingual buprenorphine are lower during than after pregnancy

JR Bastian, H Chen, H Zhang, S Rothenberger… - American journal of …, 2017 - Elsevier
Background Buprenorphine is a Food and Drug Administration–approved maintenance
therapy for opioid use disorders and is increasingly being used in pregnant women with …

Buprenorphine exposure in infants of opioid‐dependent mothers at birth

AE Bartu, KF Ilett, LP Hackett… - Australian and New …, 2012 - Wiley Online Library
Background Buprenorphine, a partial opioid agonist used in treating opioid dependence, is
not approved in Australia for use in pregnancy. Nevertheless, many pregnant women …

A Pharmacologic Evaluation of Buprenorphine in Pregnancy and the Postpartum Period

SN Caritis, R Venkataramanan - Journal of Addiction Medicine, 2024 - journals.lww.com
Background The dosing regimen in the package insert for sublingual buprenorphine is
similar for pregnant and nonpregnant people despite the physiologic changes seen during …

Maternal buprenorphine dose, placenta buprenorphine, and metabolite concentrations and neonatal outcomes

M Concheiro, HE Jones, RE Johnson… - Therapeutic drug …, 2010 - journals.lww.com
Buprenorphine is approved as pharmacotherapy for opioid dependence in nonpregnant
patients in multiple countries and is currently under investigation for pregnant women in the …

Transfer of buprenorphine into breast milk and calculation of infant drug dose

S Lindemalm, P Nydert, JO Svensson… - Journal of Human …, 2009 - journals.sagepub.com
Little is known about the safety of buprenorphine (BUP) in breastfeeding. The aim of this
work was to investigate the transfer of buprenorphine and its main active metabolite …

Preliminary buprenorphine sublingual tablet pharmacokinetic data in plasma, oral fluid, and sweat during treatment of opioid-dependent pregnant women

M Concheiro, HE Jones, RE Johnson… - Therapeutic drug …, 2011 - journals.lww.com
Background: Buprenorphine is currently under investigation as a pharmacotherapy to treat
pregnant women for opioid dependence. This research evaluates buprenorphine (BUP) …

An evidence-based recommendation to increase the dosing frequency of buprenorphine during pregnancy

SN Caritis, JR Bastian, H Zhang, H Kalluri… - American journal of …, 2017 - Elsevier
Background Dose-adjusted plasma concentrations of buprenorphine are significantly
decreased during pregnancy compared with the nonpregnant state. This observation …