Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) represent the most
severe form of pulmonary organ dysfunction driven by systemic inflammation, with a …

For patients with acute respiratory distress syndrome (ARDS) the most important objective of
mechanical ventilation is opening and keeping open the alveoli to achieve adequate …

In this issue of the Journal, Spragg and colleagues (pp. 1055–1061) report results of a
randomized, placebo-controlled, clinical trial of surfactant in adults with severe direct lung …

In this issue of Critical Care Medicine, Dr. Lutz and colleagues [1] have provided us with an
interesting study examining the effects of early surfactant administration in a porcine model …

Objective Previous studies have shown that the efficacy of exogenous surfactant is dose-
dependent during conventional positive pressure ventilation (PPV CON). The present study …

It is associated with a mortality rate of 30%(1), and the quality of life of survivors is reduced
after discharge (2). We are still lacking effective treatment, possibly in part because our …

Despite more than 25 years of extensive research, the mortality of ARDS patients remains
high. The inflammatory process within the lung and the associated gas exchange …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) 13 occur in diseases
such as sepsis and severe pneumonia49, 69 that cause diffuse inflammation in the …

The extensive pulmonary alveolar and capillary networks make the lungs highly susceptible
to cell and tissue injury from pathogens or toxic environmental agents present either in the …

In this issue of Critical Care Medicine, Dr. Willson and colleagues [1] add an important
chapter to the evolving surfactant replacement story. The study design reflects wisdom …