BACKGROUND: MR diffusion tensor imaging (DTI) appears to be a powerful method to
investigate the neuronal and axonal fibre distribution in the human brain. Changes in …

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …

Objectives Amyotrophic lateral sclerosis (ALS) is a fatal disease characterised by combined
upper and lower motor neuron degeneration. An early and accurate diagnosis is important …

Objective To assess the relationship between clinically assessed Upper Motor Neuron
(UMN) disease in Amyotrophic Lateral Sclerosis (ALS) and local diffusion alterations …

The objective of this study was to evaluate the diagnostic value of triple stimulation
technique (TST) and diffusion tensor imaging (DTI) tractography as markers of upper motor …

Introduction The brainstem is an important component in the pathology of amyotrophic
lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural …

BACKGROUND AND PURPOSE: The extensive application of advanced MR imaging
techniques to the study of ALS has undoubtedly improved our knowledge of disease …

BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

Primary lateral sclerosis (PLS) has been regarded as a rare, extreme form of amyotrophic
lateral sclerosis (ALS). Like ALS, it is a clinical diagnosis without established biomarkers …

Background The criteria for assessing upper motor neuron pathology in pure lower motor
neuron disease (LMND) still remain a major issue of debate with respect to the clinical …