Intravenous and oral l-α-acetylmethadol: pharmacodynamics and pharmacokinetics in humans
SL Walsh, RE Johnson, EJ Cone, GE Bigelow - Journal of Pharmacology …, 1998 - ASPET
Levo-α-acetylmethadol (LAAM) is a long-acting opioid agonist approved for use as a
maintenance treatment for opioid dependence. Previous clinical studies report that the onset …
maintenance treatment for opioid dependence. Previous clinical studies report that the onset …
Relative potency of levo-α-Acetylmethadol and methadone in humans under acute dosing conditions
T Eissenberg, ML Stitzer, GE Bigelow… - … of Pharmacology and …, 1999 - ASPET
levo-α-Acetylmethadol (LAAM) and methadone are full μ-opioid agonists used to treat opioid
dependence. Current labeling indicates that LAAM is less potent than methadone. Clinical …
dependence. Current labeling indicates that LAAM is less potent than methadone. Clinical …
Dose-response analysis of opioid cross-tolerance and withdrawal suppression during LAAM maintenance
EJ Houtsmuller, SL Walsh, KJ Schuh… - … of Pharmacology and …, 1998 - ASPET
Levo-α-acetylmethadol (LAAM) currently is approved as an opioid maintenance treatment.
This double-blind study was designed to characterize withdrawal suppression and opioid …
This double-blind study was designed to characterize withdrawal suppression and opioid …
1-α-Acetylmethadol (LAAM) pharmacokinetics and metabolism: current status
AL Misra, SJ Mule - The American Journal of Drug and Alcohol …, 1975 - Taylor & Francis
LAAM) is a synthetic congener [1, 21 of methadone. The presence of two asymmetric carbon
atoms in the molecule gives rise to two diastereoisomeric pairs [3] a and 0, of which the a …
atoms in the molecule gives rise to two diastereoisomeric pairs [3] a and 0, of which the a …
A randomized, open-label trial comparing methadone and levo-alpha-acetylmethadol (LAAM) in maintenance treatment of opioid addiction
J Wolstein, M Gastpar, T Finkbeiner… - …, 2009 - thieme-connect.com
Abstract Introduction: Levo-Alpha-Acetylmethadol (LAAM) is a synthetic opioid analgesic
with μ-agonistic activity and a long duration of action. There are several, almost exclusively …
with μ-agonistic activity and a long duration of action. There are several, almost exclusively …
Chronic l-α-acetylmethadol (LAAM) in rhesus monkeys: tolerance and cross-tolerance to the antinociceptive, ventilatory, and rate-decreasing effects of opioids
MR Brandt, CP France - Journal of Pharmacology and Experimental …, 2000 - ASPET
Although l-α-acetylmethadol (LAAM) is a maintenance treatment for opioid dependence, few
studies have systematically assessed the behavioral effects of LAAM and other drugs in …
studies have systematically assessed the behavioral effects of LAAM and other drugs in …
[PDF][PDF] Phase III clinical study of LAAM: report of current status and analysis of early terminations
JA Whysner, GL Levine - The International Challenge of Drug …, 1978 - archives.nida.nih.gov
Levo-alpha-acetylmethadol (LAAM) is under investigation for maintenance therapy of
persons addicted to opiate drugs. Jaffe et al.(5, 6, 7) reported that LAAM was successful as a …
persons addicted to opiate drugs. Jaffe et al.(5, 6, 7) reported that LAAM was successful as a …
Determination of l-α-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and …
W Huang, PA Bemis, MH Slawson… - Journal of pharmaceutical …, 2003 - Elsevier
ABSTRACT l-α-Acetylmethadol (LAAM) is an alternative to methadone for the maintenance
treatment of opioid dependence. LAAM has a longer therapeutic half-life than methadone …
treatment of opioid dependence. LAAM has a longer therapeutic half-life than methadone …
Levo‐alpha‐acetylmethadol (LAAM) versus methadone: treatment retention and opiate use
D Longshore, J Annon, MD Anglin, RA Rawson - Addiction, 2005 - Wiley Online Library
Aims To compare the effects of levo‐alpha‐acetylmethadol (LAAM) and methadone
maintenance (MM) on treatment retention and abstinence from opiate use. Design A two …
maintenance (MM) on treatment retention and abstinence from opiate use. Design A two …
Levomethadyl acetate (LAAM) for the treatment of opioid dependence: a multisite, open-label study of LAAM safety and an evaluation of the product labeling and …
PJ Fudala, F Vocci, A Montgomery… - … of Maintenance in the …, 1998 - Taylor & Francis
Levomethadyl Acetate (LAAM) for the Treatment of Opioid Dependence: A Multisite, Open-Label
Study of LAAM Safety and an Evaluati Page 1 Levomethadyl Acetate (LAAM) for the …
Study of LAAM Safety and an Evaluati Page 1 Levomethadyl Acetate (LAAM) for the …
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