Endogenous morphine is present in the mammalian brain as determined by gas
chromatography/mass spectrometry. The criteria essential for satisfying the defi nition of …

Background Morphine, the major alkaloid of opium of Papaver somniferum, is one of the
strongest analgesic compounds known." Endogenous morphine" has been long isolated …

Endogenous morphine has been clearly demonstrated by gas chromatography/mass
spectrometry in the brain, spinal fluid, adrenal glands, and liver of mammals. To clarify the …

Background: Morphine is the most used compound among narcotic analgesics. Apart from
its presence in the poppy plant, morphine has been shown to be endogenously present in …

Morphine has been determined in serum, cerebrospinal fluid (csf) and in five brain regions
in the rat after a single intravenous dose, using high performance liquid chromatography …

The disposition of morphine in rat brain and serum was determined over 48 hr after
subcutaneous doses. Free morphine was measured by a specific assay using 3H-labeling …

Morphine is the most widely used compound among narcotic analgesics and remains the
gold standard when the effects of other analgetic drugs are compared. Apart from its …

Materials and Methods Animals. The subjects were male Wistar rats (TNO, Zeist, the
Netherlands), weighing approximately 220 g. They were maintained in a temperature …

Misra et al.(1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1-
morphine into the rat, three radioactive compounds could be extracted from the cerebral …

Recently, we described the presence of six immunoreactive (ir) morphinans in bovine
adrenal and hypothalamus and identified one as morphine [Goldstein, A., Barrett, RW …