Morphine levels in rat brain were measured by the multiple ion detection method (mass
fragmentography), using a computer-controlled gas chromatograph-mass spectrometer, and …

Morphine is a major constituent of opium. Knowledge of opium, as a powerful remedy for
pain, led to the development of morphine as a narcotic analgesic. It had been recognized for …

1. The plasma, cardiac tissues and brain morphine concentrations in rats after acute or
chronic morphine treatment were measured by high-performance liquid chromatography. 2 …

Recently, we described three substances in bovine hypothalamus, adrenal, and rat brain
recognized by antisera raised against morphine, and we identified one as morphine and …

Morphine was first identified in opium from Papaver somniferum, and is still one of the
strongest known analgesic compounds used in hospital. Since the beginning of the 80s …

Clinical Section Page 1 Pain, 35 (1988) 121-127 Elsevier PA1 01289 121 Clinical Section
Human brain metabolism of morphine and naloxone Agneta Wahlstriim, Bengt Winblad ‘, Marie …

A highly sensitive method for the determination of morphine in plasma and brain samples
down to 500 pg ml− 1 in plasma and 100 pg in 30 mg of brain tissue is described. This …

The pharmacokinetics (uptake and elimination) and pharmacodynamics (biochemical effects
on monoamine systems) of morphine in the CNS were investigated concurrently. ICR mice …

An endogenous morphine-like substance (MLF) found in rat and calf brains has a regional
distribution correlating with that of opiate receptors, with the highest levels in the caudate …

Background: We have identified a novel mu opiate receptor, 3, which is expressed in several
human tissues, is selective for opiate alkaloids, insensitive to opioid peptides, and also is …