Codeine and morphine have been detected in mammalian brain by radioimmunoassay
(RIA), and in brain and other tissues by gas-chromatography/mass-spectrometry (GCMS) in …

1 The effect of morphine (10 mg kg− 1, sc) on the analgesic response measured by the tail‐
flick method was determined in male Sprague‐Dawley rats. The analgesic response to …

Currently available morphine radioimmunoassays, using antiserum to 3‐O‐
carboxymethylmorphine, lack sufficient specificity for clinical pharmacokinetic studies …

The disposition of serum morphine following administration of 10 mg/70 kg was determined
by a sensitive and specific radioimmunoassay in 31 anesthetized surgical patients ranging …

Biotransformation of morphine to dihydromorphinone and normorphine was studied in
several mammalian species. Free and total dihydromophinone, morphine, and normorphine …

The metabolism of opioids closely relates to their chemical structure. Opioids are subject to
O-dealkylation, N-dealkylation, ketoreduction, or deacetylation leading to phase-I …

Very few discoveries in the neurosciences have stimulated clinical speculation and
experimentation regarding the etiology of psychiatric illness to the same extent as have the …

The subcutaneous administration of 30 mgm./kgm. of morphine in nontolerant monkeys
results in the prompt appearance of free and bound morphine in the plasma, the maximum …

A sensitive isotope derivatization assay was developed to quantify morphine in biological
fluids in the nanogram per milliliter range. Morphine, derivatized with 3H‐dansyl chloride …

Recent studies have suggested that morphine-3-glucuronide (M3G) may antagonize the
analgesic effects of morphine and morphine-6-glucuronide (M6G). To investigate this …