Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2× 2 factorial placebo-controlled trial of early antiviral therapy in COVID …

DM Lowe, LAK Brown, K Chowdhury, S Davey… - PLoS …, 2022 - journals.plos.org
Background Early antiviral treatment is effective for Coronavirus Disease 2019 (COVID-19)
but currently available agents are expensive. Favipiravir is routinely used in many countries …

Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial

LAK Brown, N Freemantle, J Breuer, HM Dehbi… - Trials, 2021 - Springer
Objectives The objective of this trial is to assess whether early antiviral therapy in outpatients
with COVID-19 with either favipiravir plus lopinavir/ritonavir, lopinavir/ritonavir alone, or …

Favipiravir in patients with early mild-to-moderate coronavirus disease 2019 (COVID-19): a randomized controlled trial

Y Golan, JAS Campos, R Woolson… - Clinical Infectious …, 2023 - academic.oup.com
Background Despite vaccination, many remain vulnerable to coronavirus disease 2019
(COVID-19) and its complications. Oral antivirals to prevent COVID-19 progression are vital …

Real-world effectiveness and optimal dosage of favipiravir for treatment of COVID-19: results from a multicenter observational study in Thailand

P Rattanaumpawan, S Jirajariyavej, K Lerdlamyong… - Antibiotics, 2022 - mdpi.com
Favipiravir is a broad-spectrum oral antiviral agent that shows in vitro activity against SARS-
CoV-2. Presently, data on the real-world effectiveness and optimal dosage of favipiravir for …

Favipiravir for treatment of outpatients with asymptomatic or uncomplicated coronavirus disease 2019: a double-blind, randomized, placebo-controlled, phase 2 trial

M Holubar, A Subramanian, N Purington… - Clinical Infectious …, 2022 - academic.oup.com
Background Favipiravir, an oral, RNA-dependent RNA polymerase inhibitor, has in vitro
activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite …

[HTML][HTML] Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicentre, placebo-controlled clinical trial

M Bosaeed, A Alharbi, E Mahmoud, S Alrehily… - Clinical Microbiology …, 2022 - Elsevier
Objective To evaluate whether favipiravir reduces the time to viral clearance as documented
by negative RT-PCR results for severe acute respiratory syndrome coronavirus 2 in mild …

Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial

JH McMahon, JSY Lau, A Coldham, J Roney… - …, 2022 - thelancet.com
Background Well tolerated antivirals administered early in the course of COVID-19 infection
when the viremia is highest could prevent progression to severe disease. Favipiravir inhibits …

Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial

V Luvira, WHK Schilling, P Jittamala, JA Watson… - BMC Infectious …, 2024 - Springer
Brief summary In early symptomatic COVID-19 treatment, high dose oral favipiravir did not
accelerate viral clearance. Background Favipiravir, an anti-influenza drug, has in vitro …

[HTML][HTML] Efficacy and safety of favipiravir in a complex therapy of mild to moderate COVID-19

TA Ruzhentsova, PV Chukhlyaev… - Infectious diseases …, 2020 - infect-dis-journal.ru
Aim of the study-to assess the efficacy and safety of favipiravir for treatment of mild to
moderate coronavirus disease (COVID-19). Material and methods. An open-labeled …

Understanding the clinical utility of favipiravir (T-705) in coronavirus disease of 2019: A review

K Srinivasan, M Rao - Therapeutic Advances in Infectious …, 2021 - journals.sagepub.com
The coronavirus disease of 2019 (COVID-19) has caused significant morbidity and mortality
among infected individuals across the world. High transmissibility rate of the causative virus …