The present study, investigates the effect of RBx 6198, 2-{3-[4-(2-Isopropoxy-phenyl)-
piperazin-1-yl]-propyl}-3a, 4, 7, 7a-tetrahydro-isoindole-1, 3,-dione, a novel α1-adrenoceptor …

New types of α1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are
currently receiving a great deal of attention, especially in terms of developing effective …

New compounds selective for α1A‐adrenoceptors in the prostate may offer enhanced
efficacy for benign prostatic hyperplasia (BPH), with fewer side effects than current …

Several α1-adrenoceptor (AR) selective antagonists are now widely used to improve lower
urinary tract symptoms in benign prostatic hyperplasia patients. However, these drugs often …

Benign prostatic hyperplasia (BPH) is highly prevalent in the male population beyond the
age of 60. Impairment of urinary flow due to prostate enlargement gives rise to symptoms of …

The development of α 1a-adrenergic receptor (AR) subtype-selective antagonists is likely to
result in uroselective agents that effectively treat benign prostatic hyperplasia (BPH) …

Symptomatic benign prostatic hyperplasia (BPH) is a common condition in older men and
has a significant impact on their daily lives. Transurethral resection of the prostate is …

We examined the effect of JTH-601 (3-{N-[2-(4-hydroxy-2-isopropyl-5-methylphenoxy) ethyl]-
N-methylaminomethyl}-4-methoxy-2, 5, 6-trimethylphenol hemifumarate), a new α1L …

Synopsis Tamsulosin is the first subtype-selective (α 1A) α 1 adrenoceptor antagonist with
specificity for prostatic α 1 adrenoceptors (α 1A adrenoceptors are thought to be involved in …

A-131701 (3-[2-((3aR, 9bR)-cis-6-methoxy-2, 3, 3a, 4, 5, 9b, hexahydro-[1H]-benz [e]
isoindol-2-yl) ethyl] pyrido [3′, 4′: 4, 5] thieno [3, 2-d] pyrimidine-2, 4 (1H, 3H)-dione) is a …