Spinal muscular atrophy (SMA) is a neuromuscular disease characterised primarily by loss
of lower motor neurons from the ventral grey horn of the spinal cord and proximal muscle …

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting
primarily from the degeneration and loss of lower motor neurons. Studies using mouse …

Low levels of survival of motor neuron (SMN) protein lead to spinal muscular atrophy (SMA).
The major pathological hallmark of SMA is a loss of lower motor neurons from spinal cord …

The loss of motor neurons (MNs) is a hallmark of the neuromuscular disease spinal
muscular atrophy (SMA); however, it is unclear whether this phenotype autonomously …

Survival of motor neuron (SMN) deficiency causes spinal muscular atrophy (SMA), but the
pathogenesis mechanisms remain elusive. Restoring SMN in motor neurons only partially …

Spinal muscular atrophy (SMA) is a devastating genetic neuromuscular disease. Diffuse
neuropathology has been reported in SMA patients and mouse models, however, functional …

Spinal muscular atrophy (SMA) is a progressive neuromuscular disorder caused by a loss of
the survival of motor neuron 1 (SMN1) gene, resulting in a loss of spinal motor neurons …

Motoneuron (MN) cell death is the histopathologic hallmark of spinal muscular atrophy
(SMA), although MN loss seems to be a late event. Conversely, disruption of afferent …

In the inherited childhood neuromuscular disease spinal muscular atrophy (SMA), lower
motor neuron death and severe muscle weakness result from the reduction of the …

The childhood motor neuron disease spinal muscular atrophy (SMA) results from reduced
expression of the survival motor neuron (SMN) gene. Previous studies using in vitro model …