Estimating prevalence of early Alzheimer's disease in the United States, accounting for racial and ethnic diversity

C Gillis, P Montenigro, M Nejati… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Updated estimates of the US Alzheimer's disease (AD) population, including
under‐represented populations, are needed to improve clinical trial diversity. Methods A …

A global view of the genetic basis of Alzheimer disease

C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …

Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer's disease risk

D Shigemizu, R Mitsumori, S Akiyama… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) has no cure, but early detection and risk prediction could allow
earlier intervention. Genetic risk factors may differ between ethnic populations. To discover …

Improving generalizability and study design of Alzheimer's disease cohort studies in the United States by including under‐represented populations

MR Mindt, O Okonkwo, MW Weiner… - Alzheimer's & …, 2023 - Wiley Online Library
The poor generalizability of clinical research data due to the enrollment of highly educated,
non‐Latinx White participants hampers the development of therapies for Alzheimer's …

Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis

BW Kunkle, M Schmidt, HU Klein, AC Naj… - JAMA …, 2021 - jamanetwork.com
Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …

[HTML][HTML] Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's …

WP Lee, SH Choi, MG Shea, PL Cheng, BA Dombroski… - medRxiv, 2023 - ncbi.nlm.nih.gov
Alzheimer's Disease (AD) is a common disorder of the elderly that is both highly heritable
and genetically heterogeneous. Here, we investigated the association between AD and both …

Racially diverse participant registries to facilitate the recruitment of African Americans into presymptomatic Alzheimer's disease studies

S Cocroft, KA Welsh‐Bohmer… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Prevention Registry (ADPR) of the Joseph
and Kathleen Bryan Alzheimer's Disease Research Center at Duke University has been …

Transferability of Alzheimer disease polygenic risk score across populations and its association with Alzheimer disease-related phenotypes

SH Jung, HR Kim, MY Chun, H Jang, M Cho… - JAMA network …, 2022 - jamanetwork.com
Importance Polygenic risk scores (PRSs), which aggregate the genetic effects of single-
nucleotide variants identified in genome-wide association studies (GWASs), can help …

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimers Disease in individuals of …

NR Ray, BW Kunkle, K Hamilton-Nelson, JT Kurup… - medRxiv, 2023 - medrxiv.org
INTRODUCTION: Despite a two-fold increased risk, individuals of African ancestry have
been significantly underrepresented in Alzheimers Disease (AD) genomics efforts …

The Alzheimer's disease sequencing project–follow up study (ADSP‐FUS): Increasing ethnic diversity in Alzheimer's genetics research with addition of potential new …

PR Mena, BW Kunkle, K Faber, K Celis… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Background The ADSP‐FUS is a National Institute on Aging (NIA) initiative focused
on identifying genetic risk and protective variants for late‐onset Alzheimer Disease (LOAD) …