The purpose of this project was to characterize the dose-dependent pharmacokinetics of
buprenorphine (BN) and norbuprenorphine (NBN), the primary metabolite, after intravenous …

Background Prescribed sublingual (SL) buprenorphine is sometimes diverted for
intravenous (IV) abuse, but no human pharmacokinetic data are available following high …

INTRODUCTION: A specific, accurate, and reproducible liquid chromatography–mass
spectrometric (LC/MS) method was developed and validated that allows simultaneous …

Objective The aim of this investigation was to characterize the pharmacokinetics of
buprenorphine following administration of an intravenous (iv) infusion. To date, the …

Buprenorphine is a potent partial-opioid agonist that is used as an analgesic in animals
and humans to ameliorate moderate to severe pain and in the treatment of opiate addiction …

Buprenorphine (BUP), a synthetic opioid analgesic, is frequently abused alone, and in
association with benzodiazepines. Fatalities involving buprenorphine alone seem very …

The relationships between plasma or brain concentrations and analgesic effects of both
buprenorphine(BN) and an active metabolite, norbuprenorphine(NBN), were investigated in …

A sensitive, specific, and robust capillary gas chromatography–mass spectrometry method
has been developed and validated for simultaneous determination of buprenorphine and its …

The purpose of this study was to evaluate plasma concentrations and pharmacokinetic
parameters of buprenorphine in dogs following intravenous (IV) administration of clinical …

The pharm. cokinedc charactrlstlcs of buprenorphine(BN) and its actlv#{149} metabOIfte, no,
buprenorphln(NBN), was Investigated using rats. Thi elimination half-life (t112), total body …