… with prostate cancer in genome-wide association studies, few … more likely to develop
early-onset prostate cancer, which is … the risk of adverse pathology (extraprostatic extension or …

… Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of
prostate cancer. To compare the genomic alteration landscapes of EO-PCA with “classical” (elderly…

… -wide association studies have led to … early onset of the disease and men with inherited
germline variants in DNA repair genes are particularly at risk for harbouring aggressive histology. …

… young gastric cancer patients have a positive family history, … of GC are the World Health
Organization (WHO) and the … prostate cancers. A proportion of hereditary nonpolyposis colorectal …

… prevalence of family history of cardiovascular disease in male … significant positive association
between prostate cancer and … of BPH, which is also an androgen dependent pathology. …

… of aggressive clinical behavior, … prostate, including the impact of family history of disease
risk, the nature of structural genetic aberrations, and the possible role of oncogenes and tumor …

… association between BRCA2 mutations and prostate cancer … about the potential association
between BRCA2 mutations … of medical records, pathology reports, and histology slides (to …

… 160 pedigrees); strength of family history according to number of men … It is obtained by adding
two histological pattern … for prostate cancer, yet other genes influence the clinical course of …

… least 2 relatives with early-onset (<55 years old) disease (9% … World Health Organization
(WHO) reviewed the histological … , necessitating a response by the Pathology community. Thus, …

… family history of other cancer types however, especially with respect to early-onset and lethal
disease … evidence demonstrated for strong associations with early-onset and familial PrCa, …