A case series of concomitant treatment of perhexiline with amiodarone

H Gilutz, MP Frenneaux… - Therapeutic drug …, 2012 - journals.lww.com
… 26 patients received this concomitant treatment without any … that concomitant treatment with
perhexiline and amiodarone may be … of plasma perhexiline concentrations to guide therapy. …

Can perhexiline be utilized without long-term toxicity? A clinical practice audit

H Phuong, BY Choi, CR Chong, B Raman… - Therapeutic drug …, 2016 - journals.lww.com
… with potentially interacting drugs (such as amiodarone, 25 … ) were not contraindications to
perhexiline therapy at entry. … details regarding concomitant CYP2D6 inhibitor therapy, this study …

Perhexiline and hypertrophic cardiomyopathy: a new horizon for metabolic modulation

JD Horowitz, YY Chirkov - Circulation, 2010 - Am Heart Assoc
… increased significantly by perhexiline therapy, with concomitant and marked amelioration …
case for the development of agents with less potential toxicity than amiodarone and perhexiline

Perhexiline improves symptomatic status in elderly patients with severe aortic stenosis

SA Unger, MA Robinson… - Australian and New …, 1997 - Wiley Online Library
report here our initial experience with perhexiline treatment … in this group of patients over
the first three months of therapy. … evidence of concomitant coronary artery disease. In addition, …

Dronedarone, amiodarone and other antiarrhythmic drugs, and acute liver injuries: a case-referent study

L Grimaldi-Bensouda, H Wedemeyer, J Wiegand… - International Journal of …, 2018 - Elsevier
… Exposure to class III antiarrhythmic drugs was 4.0% in cases and 1.5% in controls, aOR =
3.6 (95% CI: 1.6–8.4). Associations with exposure to dronedarone and amiodarone were …

Randomized controlled trial of perhexiline on regression of left ventricular hypertrophy in patients with symptomatic hypertrophic cardiomyopathy (RESOLVE-HCM trial …

R Ananthakrishna, SL Lee, J Foote, BC Sallustio… - American Heart …, 2021 - Elsevier
… • Current treatment with perhexiline or previous adverse reaction to perhexiline at therapeutic
… of recurrent hypoglycemia• Concomitant use of amiodarone, ranolazine or trimetazidine• …

Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease

SM Killalea, H Krum - American Journal of Cardiovascular Drugs, 2001 - Springer
… documented with amiodarone.[61] … concomitant plasma perhexiline concentrations ranging
between 720 and 2680 μg/L. Subsequently, another group of 22 similar patients were treated

Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy

RM Beadle, LK Williams, M Kuehl, S Bowater… - JACC: Heart Failure, 2015 - jacc.org
… Each JACC Patient Care Pathway is an immersive, multimedia case report depicting the …
than twice the upper limit of normal; concomitant use of amiodarone, quinidine, haloperidol, or …

[PDF][PDF] A Phase 2, Multi-Center, Open-Label, Ascending Dose Study on the Efficacy, Safety and Tolerability of Perhexiline in Patients with Hypertrophic …

US IND - classic.clinicaltrials.gov
… Any concomitant disease, condition, or treatment that could interfere with the conduct of the
study, or that would, in the opinion of the investigator or sponsor, pose an unacceptable risk …

Drugs that affect cardiac metabolism: focus on perhexiline

CR Chong, B Sallustio, JD Horowitz - Cardiovascular drugs and therapy, 2016 - Springer
… for such therapies (for example because of concomitant severe systolic heart failure) and
by the … of the anti-ischaemic effects of perhexiline and amiodarone. However, excessive or …