… function of Stat3 in in vivo megakaryopoiesis, we generated mice selectively bearing the
dominant-negative form of Stat3 … inhibited in vivo Stat3 activation, we examined whether Stat3 is …

… that both STAT3 and STAT5 are essential for normal regulation of megakaryopoiesis. First,
both … hematopoietic cells, IFN-γ promotes megakaryopoiesis both in vivo and in vitro (22–24). …

… of the disease state. … -state megakaryopoiesis was significantly elevated as expected,
we unexpectedly observed that Jak2-mutant Mks/platelets significantly increased steady-state …

… MK formation (megakaryopoiesis) and subsequent platelet production are complex … and
molecular regulations of megakaryopoiesis. The current state of the ex vivo production of MKs …

… relationship between ploidy and steady-state platelet counts. … for Gata1 in both
megakaryopoiesis and erythropoiesis, … syndrome rescued defective megakaryopoiesis in vitro, 77 …

… To test whether the absence of Stat1 had an effect on intracellular signaling by other Stat
proteins, we examined the in vivo steady-state phosphorylation of Stat3 (pStat3) and Stat5 (…

… the role of IL-21 on megakaryopoiesis, using in vitro assays with human cells and in vivo …
These observations are in line with the documented role of STAT3 in megakaryopoiesis. In the …

… vitro, we found that ingenol was able to promote MK differentiation with no cytotoxicity.
Furthermore, in vivo … RIT, enhance platelets level and stimulate megakaryopoiesis in c-MPL knock-…

… To discover novel genetic determinants of megakaryopoiesis and platelet formation, we
performed meta-analyses of GWAS for mean platelet volume (MPV) and platelet count (PLT). …

… To investigate the role of STAT3 mutations in vivo, we performed … C57BL/6 mice transduced
with STAT3 Y640F, STAT3 WT or empty … for granulopoiesis and megakaryopoiesis. Indeed, …