[PDF][PDF] 14 Agents Used in Cardiac Arrhythmias

RD Harvey, AO Grant - Basic & clinical pharmacology, 2018 - academia.edu
… for arrhythmias associated with digitalis toxicity, excess … action is very similar to that of
quinidine, but it does not prolong … organ system, amiodarone treatment should be reevaluated …

Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk …

J Bentz, MP O'Connor, D Bednarczyk… - Drug metabolism and …, 2013 - ASPET
… telmisartan and verapamil, respectively. For telmisartan and verapamil, variability was greatly
… brings the range in IC 50 values for telmisartan and verapamil down to 69- and 159-fold. …

Cytochrome P450-mediated cardiovascular drug interactions

AJ Scheen - Expert Opinion on Drug Metabolism & Toxicology, 2011 - Taylor & Francis
… has been observed to inhibit the metabolism of digoxin, tricyclic … Verapamil impairs the
metabolism of quinidine to 3-… may also act as CYP3A4 inhibitors (amiodarone, quinidine, …

Pharmacokinetic drug interactions

EA Hartshorn - 1985 - journals.sagepub.com
is that quinidine displaces digoxin from its binding sites in skeletal (and perhaps cardiac)
muscle, although this explanation is not … drugs that increase digoxin serum levels (amiodarone; …

[PDF][PDF] THERAPEUTIC PLASMA CONCENTRATIONS

MS Boro, ME Winter - downloads.lww.com
… that amiodarone like quinidine may cause variations of digoxin … report would suggest that
amiodarone may in fact change … steady-state digoxin concentrations associated with verapamil. …

P-glycoprotein-mediated renal tubular secretion of digoxin: the toxicological significance of the urine-blood barrier model

S Ito, C Woodland, PA Harper, G Koren - Life sciences, 1993 - Elsevier
… evidence that verapamil inhibits active digoxin secretion … quinidine, verapamil, amiodarone,
spironolactone and cyclosporine resulted in conversion to net tubular reabsorption of digoxin

[PDF][PDF] Agents used in cardiac arrhythmias

JR Hume, AO Grant - Basic & clinical pharmacology, 2007 - academia.edu
… for some arrhythmias related to digitalis excess, to … of action is very similar to that of quinidine,
but it does not prolong … every organ system, amiodarone treatment should be reevaluated …

Basic pharmacology of cardiac drugs

TJ Campbell - Interventional Cardiology and Cardiac …, 2019 - taylorfrancis.com
Verapamil also interacts with digoxin and may produce a … Administration of quinidine to a
patient already on digoxin leads to an … These include verapamil, amiodarone, propafenone and …

Therapeutic drug monitoring of antiarrhythmic drugs

G Jürgens, NA Graudal, JP Kampmann - Clinical pharmacokinetics, 2003 - Springer
… For amiodarone, the active metabolite desethyl-amiodarone … concentration-effect curves,
as suggested for digoxin[76]and … Quinidine is bound to α 1 -acid glycoprotein, and the binding

Overview of the clinical pharmacology of antiarrhythmic drugs

RL Woosley, C Funck-Brentano - The American journal of cardiology, 1988 - Elsevier
… patients receiving quinidine and digoxin concurrentl~.~ This interaction is dependent on
quinidine dosage, and … However, it is not known how amiodarone alters elimination of drugs that …