Antibiofilm activity of host defence peptides: complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
… In addition, we compare and contrast the complex effects of antibiofilm peptides on bacterial
… immunomodulatory activities of host defence peptides beyond their antimicrobial activity. …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
work by our group has implicated the widespread bacterial stringent response as a common
target for the antibiofilm activity of … of length n (the problem becomes exceedingly complex if …

Anti-biofilm peptides as a new weapon in antimicrobial warfare

D Pletzer, SR Coleman, REW Hancock - Current opinion in microbiology, 2016 - Elsevier
… -derived peptide AS10 had specific anti-biofilm activity at a … that show how anti-biofilm
peptides work on a molecular … Interrupting complex regulatory systems without killing bacteria …

Antibiofilm peptides: potential as broad-spectrum agents

D Pletzer, REW Hancock - Journal of bacteriology, 2016 - Am Soc Microbiol
… synthetic peptides with broad-spectrum antibiofilm activity … changes, and these provide both
an opportunity and a substantial … Antimicrobial peptides have complex mechanisms of action, …

[HTML][HTML] The potential of human peptide LL-37 as an antimicrobial and anti-biofilm agent

KE Ridyard, J Overhage - Antibiotics, 2021 - mdpi.com
… spectrum antibacterial and anti-biofilm activities as well as … between charge and antimicrobial
activities is complex, and … Likewise, LL-37 derivatives have been reported to work in …

[HTML][HTML] Synthetic antibiofilm peptides

C De La Fuente-Núñez, MH Cardoso… - … et Biophysica Acta (BBA …, 2016 - Elsevier
… This review provides an overview of recent work describing … ) and anti-biofilm activity and
the most interesting peptide was … of these peptides are quite long or chemically complex and …

The immunology of host defence peptides: beyond antimicrobial activity

REW Hancock, EF Haney, EE Gill - Nature Reviews Immunology, 2016 - nature.com
… b | LL-37 has more than 1,000 first-order interaction partners (… the complexity of the actions
of the host defence peptide LL-37 … , and much of this work has focused on the stimulation of …

[HTML][HTML] Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

EF Haney, MJ Trimble, JT Cheng, Q Vallé… - Biomolecules, 2018 - mdpi.com
… to assess the activity of antibiofilm agents has not been established. In the present work, we
describe … Evidently, it appears that we must appreciate the complexity of biofilm growth when …

[HTML][HTML] Biofilms: Novel strategies based on antimicrobial peptides

E Galdiero, L Lombardi, A Falanga, G Libralato… - Pharmaceutics, 2019 - mdpi.com
… in more complex structures known as … antimicrobial action of the peptides but also overcome
their disadvantages [49,50,51]. Nanotechnology offers a number of promising opportunities

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

P Jorge, A Lourenco, MO Pereira - Biofouling, 2012 - Taylor & Francis
… AMP-based strategies and discusses ongoing and future work. … in the evolution of complex
multicellular organisms. Despite … Besides their antimicrobial action, AMPs can also influence …