… theraupetic effect of sirolimus in the relief of pain in rat model of adjuvant-induced arthritis.
The … in the spinal cord of arthritic rats has also been investigated to clarify the mechanism of …

… with T lymphocyte inhibitory effects are used in neuropathic pain models. However, sirolimus
has been used orally to treat developing adjuvant arthritic rats, a T-cell mediated rat model, …

… Because various arthritic inflammatory disorders are highly … drugs needed to produce
an antihyperalgesic effect of 50% (… (an adjuvant analgesic drug) in a rat model of somatic …

… Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis. …
Evaluation of complete freund’s adjuvantinduced arthritis in a wistar rat model (comparison of …

… sirolimus induces antiallodynic and antihyperalgesic effects in rats subjected to CCI [152]
or adjuvant-induced arthritis [… an antiallodynic effect in a rat model of diabetic neuropathy [173]. …

… (2013) [6] reported that sirolimus decreases the arthritic lesions and paw edema and exhibits
antihyperalgesic and anti-allodynic activities in a model of rat adjuvant-induced arthritis. …

… Overall performance in AA rats models the clinical manifestations in RA patients. Injection
of FCA into the toe joints led to an early stage inflammatory response and aggravated TSD. …

… determine the effects of gabapentinoids in animal models of … This indicates that the in vivo
antiallodynic effects of chronic … effective in arthritic and neuropathic rats but not normal rats; …

… exerted antihyperalgesic effects in animal models of arthritis [… an acetic acid-induced
hyperalgesia model [Citation14] and … In rodents, sirolimus is antihyperalgesic both in inflammatory …

… In animal models of arthritis it leads to a decrease in histopathologic changes of bone …
Sirolimus and combination therapy with cyclosporin A in the rat developing adjuvant arthritis model…