Virus entry as a target for anti-HIV intervention

JA Esté - Current medicinal chemistry, 2003 - ingentaconnect.com
… Of these, dextran sulfate (DS), heparin, pentosan sulfate Fig. (… inhibited HIV-1 infection
mediated by CCR5 of six R5 HIV-1 … group was the preferred moiety for derivatization of the N(4) of …

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides

CR Wagner, VV Iyer, EJ McIntee - Medicinal research reviews, 2000 - Wiley Online Library
… This approach of derivatization has been applied using … AZT-TP formation was found to be
necessary for anti-HIV-1 activity.In … Permeabilization of the L929 TKÀ cells with dextran sulfate …

[PDF][PDF] Glyconanoparticles for targeting macrophages to deliver therapeutic agents

T Mosaiab - 2018 - core.ac.uk
… aureus infected macrophages and results showed significant … antimicrobial inhibition upon
incubating with these GNPs. … Furthermore, a doxorubicin/dextran sulphate complex was …

Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates—proof of concept for HIV mucosal pre-exposure prophylaxis

M Samizadeh, X Zhang, S Gunaseelan… - Drug delivery and …, 2016 - Springer
… endocytosis marker, tetramethylrhodamine dextran (Rho Dex, 10 … the inhibition of syncytium
formation in HIV-1 infected MT-2 T … with the chemical derivatization process presented in this …

Charge modification of plasma and milk proteins results in antiviral active compounds

PJ Swart, MC Harmsen, ME Kuipers… - Journal of Peptide …, 1999 - Wiley Online Library
… the charge density of the derivatized proteins, the more potent … 3 the antiviral activity versus
the l charge/AA for HIV-1 is … on a molar basis than the dextran sulfate tested in our series. …

[HTML][HTML] M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures

G Musumeci, I Bon, D Lembo, V Cagno, MC Re… - Scientific reports, 2017 - nature.com
… (PBMCs) infected with R5- and X4–tropic HIV-1 strains. The … to protect women from HIV-1
infection, especially since … medium with 7.5 μg/mL of DEAE-dextran (Sigma) in a final volume of …

[PDF][PDF] Endogenous CXCR4 antagonists: role in HIV-1 transmission and therapy of CXCR4-linked diseases

M Harms - 2022 - oparu.uni-ulm.de
… [175] Evidence for this kind of restriction mechanism might be the association of resistance
against R5-tropic HIV-1 infection with increased levels of the CCR5 ligand RANTES in some …

A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

A Gadekar, S Bhowmick… - Advanced Functional …, 2020 - Wiley Online Library
… , alveolar macrophages, peritoneal macrophages, splenic … to perform reductive amination
to derivatize with di-hydrazide … [ 171 ] The dextran-based nanogels conjugated with a wide …

(Glyco)-protein drug carriers with an intrinsic therapeutic activity: the concept of dual targeting

DKF Meijer, G Molema, F Moolenaar… - Journal of controlled …, 1996 - Elsevier
… Then HIV-1 infected HUT-78 cells were added to the wells, … Remarkable antiviral activity was
found after derivatization of … contrasts with polyanions such as dextran sulfate. In contrast to …

[PDF][PDF] Plantas com efeito na AIDS-SIDA-HIV positivo

P Viñas, J de Felippe Junior - Biol Pharm Bull, 1998 - medicinacomplementar.com.br
HIV-1 infection and showed inhibitory activity against HIV-1 … Unlike dextran sulfate, the
plant lectins CA, EHA and UDA … of peripheral blood mononuclear cells, monocyte/macrophages