Transcriptomic analysis of paired healthy human skeletal muscles to identify modulators of disease severity in DMD
S Nieves-Rodriguez, F Barthélémy, JD Woods… - Frontiers in …, 2023 - frontiersin.org
… and healthy TA in our transcriptome-wide analysis. PDK4, … used to identify splicing factors
co-expressed in single cells … the challenges of isoform quantification caused by 3’ bias, low …
co-expressed in single cells … the challenges of isoform quantification caused by 3’ bias, low …
[PDF][PDF] Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS
… of AML cells, with RG3039, and performed RNA sequencing (RNA-seq) to determine
potential transcriptome-wide splicing changes (Figure 4A). Of note, CETSA analysis showed …
potential transcriptome-wide splicing changes (Figure 4A). Of note, CETSA analysis showed …
Dysregulated Spliceosome Gene Expression May Be a Common Process in Brains of Neurological and Psychiatric Disorders
… splicing is observed in several neurological and psychiatric disorders. While exonic mutations
usually affect the splicing of an individual RNA, mutations in the splicing … below brie y …
usually affect the splicing of an individual RNA, mutations in the splicing … below brie y …
Computational and Machine Learning Methods for Understanding Gene Regulation and Variant Effects
GS Benegas - 2023 - escholarship.org
… the analysis of alternative splicing — a crucial but overlooked step in gene regulation — from
short-read single-cell … Instead of using single cells as replicates, we partitioned the BICCN …
short-read single-cell … Instead of using single cells as replicates, we partitioned the BICCN …
Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics
… single cells from adult human prefrontal cortex (24), we assembled a cell type–specific
reference panel for seven major brain cell … brain expression and splicing quantitative trait locus (…
reference panel for seven major brain cell … brain expression and splicing quantitative trait locus (…
[图书][B] Genomic characterisation of Alzheimer's disease risk genes using long-read sequencing
SK Leung - 2022 - search.proquest.com
… Transcriptome-wide … 2,800 single cells, identifying thousands of cell-speci c novel isoforms
and di erential isoform usage between cell lines for genes enriched in mRNA splicing and cell…
and di erential isoform usage between cell lines for genes enriched in mRNA splicing and cell…
Comparative analyses uncover a link between mRNA splicing, stability, and RNA covalent modifications in flowering plants
… Brie y, this work ow maps reads to each species’ reference genome (obtained from Ensembl
Plants … Transcriptome-wide analysis of pseudouridylation of mRNA and non-coding RNAs in …
Plants … Transcriptome-wide analysis of pseudouridylation of mRNA and non-coding RNAs in …
[图书][B] Integrative Omics Data Analysis to Discover Novel Signatures in Complex Diseases
L Pan - 2023 - search.proquest.com
… splicing variants with the genetic patterns from different regions of the brain in normal individuals
to identify quantitative … of individual cells, reveal complex and novel cell populations that …
to identify quantitative … of individual cells, reveal complex and novel cell populations that …
LncSEA 2.0: an updated platform for long non-coding RNA related sets and enrichment analysis
G Zhang, C Song, S Fan, M Yin, X Wang… - Nucleic Acids …, 2024 - academic.oup.com
… analysis functions based on GSEA and GSVA. (iv) We adopted the snakemake analysis
pipeline to track data processing and analysis. … variety of enrichment analysis modules, assisting …
pipeline to track data processing and analysis. … variety of enrichment analysis modules, assisting …
Systems biology of deregulated splicing in cancer. A pan-cancer analysis of dysfunctional splicing machinery and alternative splicing events.
L Castillon - 2021 - odr.chalmers.se
… arise from a single cell, which is known as the monoclonal origin of tumors. However, there
… has been studied using RNA-sequencing, which enables transcriptome-wide profiling of the …
… has been studied using RNA-sequencing, which enables transcriptome-wide profiling of the …