Role of metabolic H2O2 generation: redox signaling and oxidative stress

H Sies - Journal of Biological Chemistry, 2014 - ASBMB
… Metabolically generated H 2 O 2 emerged from recent research as a central hub in redox
signaling and oxidative stress. Upon generation by major sources, the NADPH oxidases or …

Biochemistry of oxidative stress

H Sies - Angewandte Chemie International Edition in English, 1986 - Wiley Online Library
oxidative reactions. Oxidative damage inflicted by reactive oxygen species has been called
“… This review article is concerned with oxidative damage in biological systems. First of all, the …

[HTML][HTML] Oxidative stress

GJ Burton, E Jauniaux - Best practice & research Clinical obstetrics & …, 2011 - Elsevier
… potentially damaging side-effects for biological systems. Reactivity allows oxygen to participate
… Free radicals can be generated from many elements, but in biological systems it is those …

On the history of oxidative stress: Concept and some aspects of current development

H Sies - Current Opinion in Toxicology, 2018 - Elsevier
Oxidative stress as a concept in redox biology and medicine has witnessed fulminant
development of the past 30-odd years. It is a global concept, defined as “an imbalance between …

Iron, oxidative stress, and redox signaling in the cardiovascular system

A Gudjoncik, C Guenancia, M Zeller… - Molecular nutrition & …, 2014 - Wiley Online Library
… The respiratory chain relies on iron-containing redox systems in the form of complexes I–III
with Fe–S clusters and cytochromes with heme as prosthetic groups. As we previously …

Oxidative stress and antioxidants: biological response modifiers of oxidative homeostasis in cancer

A Čipak Gašparović, T Lovaković, N Žarković - Periodicum biologorum, 2010 - hrcak.srce.hr
Oxidative stress is defined as a misbalance in cell redox reactions resulting in the increase
… /or decreased antioxidant defence. Crucial part of oxidative stress, which avoids protective ef…

Oxidative stress and cancer: the role of redox regulation

S Toyokuni - Biotherapy, 1998 - Springer
Oxidative stress in tumor biology The research history of oxidative stress in carcinogenesis …
However, the research on oxidative stress in tumor biology has just begun in the late 80’s. …

[PDF][PDF] What is oxidative stress?

T Yoshikawa, Y Naito - Japan medical association journal, 2002 - Citeseer
… Many of the genes that are associated with biological oxidative stress have been identified,
with the genes for NO synthetase (NOS) and heme oxygenase (HO) being considered as …

[PDF][PDF] Some current insights into oxidative stress.

Z Ďuračková - Physiological research, 2010 - researchgate.net
… and they prevent oxidation of biologically important molecules by FR or RM. (c) If protection
of the organism fails at this level, then repair systems recognize impaired molecules and …

Redox proteomics: chemical principles, methodological approaches and biological/biomedical promises

A Bachi, I Dalle-Donne, A Scaloni - Chemical reviews, 2013 - ACS Publications
… responses to oxidative stress are often mediated by redox-… , whose redox-active cysteine
residues are targets for redox … both redox systems, the high ratios of reduced to oxidized form …