Degree of fibrosis in human atrial tissue is not the hallmark driving AF

K S. Ramos, L Pool, MS van Schie, LFJM Wijdeveld… - Cells, 2022 - mdpi.com
atrial fibrillation (AF). In this current study, we investigated the relation between the degree
of fibrosis in human atrial tissue samples of controls and patients in … did not correlate with the …

Novel molecular targets for atrial fibrillation therapy

D Dobrev, L Carlsson, S Nattel - Nature reviews Drug discovery, 2012 - nature.com
… the underlying molecular determinants of atrial fibrillation, and … anti-atrial fibrillation drugs,
on the molecular and structural … ectopic activity to induce re-entry in remodelled vulnerable …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
… of triggered ectopic activity and for the activation of Ca 2+ -related cell signaling that …
and their plasma concentrations have been found to correlate with the risk of AF, suggesting …

Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation

N Gaborit, M Steenman, G Lamirault, N Le Meur… - Circulation, 2005 - Am Heart Assoc
… The input consisted of median replicate expression values (displayed as log-normal) for
each gene and patient. Clustering with uncentered correlation with the CLUSTER program 20 …

Electrophysiological correlation and prognostic impact of heat shock protein 27 in atrial fibrillation

YF Hu, HI Yeh, HM Tsao, CT Tai, YJ Lin… - … : Arrhythmia and …, 2012 - Am Heart Assoc
… The electrophysiological study, the contact electroanatomical mapping, signal analysis,
identification of pulmonary vein and nonpulmonary vein ectopic beats, catheter ablation of AF, …

Current controversies in determining the main mechanisms of atrial fibrillation

U Schotten, D Dobrev, PG Platonov… - Journal of internal …, 2016 - Wiley Online Library
… AF, the contribution of ectopic (triggered) activity caused by … in the right and left atria in patients
with paroxysmal AF, … the atrial myocardium showed strong and significant correlation with …

[PDF][PDF] New aspects of pathogenesis of atrial fibrillation: remodelling of intercalated discs

N Tribulova, T Egan Benova, B Szeiffova Bacova… - J. Physiol …, 2015 - jpp.krakow.pl
… a prime source of ectopic electrical activity, and radiofrequency … of AF in over 75% of patients
(1, 2). Electrophysiological basis … Structural correlate of atrial fibrillation in human patients. …

The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm

S Kapur, CA MacRae - Frontiers in Physiology, 2013 - frontiersin.org
… In this review we use atrial fibrillation as a generalizable example … ectopic foci during AF.
Therefore, it is likely that the arrhythmogenic activity of PVs may be an important cause of “atrial

Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance

M Gawałko, A Saljic, N Li, I Abu-Taha… - Cardiovascular …, 2023 - academic.oup.com
… cardiac fat correlates with dilatation of the left atrium (LA), a … The ectopic (triggered) activity
is often the result of Ca 2+ -… cell-to-cell coupling and voltage-gated Na + channels governing …

Cardiomyocyte remodeling in atrial fibrillation and hibernating myocardium: shared pathophysiologic traits identify novel treatment strategies?

BR Weil, C Ozcan - BioMed research international, 2015 - Wiley Online Library
… protein calpain I that correlated with ERP shortening, atrial myocyte structural remodeling, …
in atrial myocardium and pulmonary sleeve may prevent triggers, reentry, and ectopic activities