… for using selective COX-2 inhibitors in cancer chemoprevention, and outline new avenues
of … that are necessary to allow their successful use in patients at risk for colorectal cancer. …

… Colorectal cancer (CRC) is a leading cause of cancer-related … Chemoprevention aims to
prevent the development or … The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial …

… 25 Bertagnolli MM: Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors:
two steps forward, one step back. Lancet Oncol 2007; 8: 439–443. 26 Rao CV, Reddy BS: …

… Aspirin is the best chemoprevention agent for colorectal cancer risk reduction despite the …
The cyclooxygenase-2 selective agents (COXIBS) have an efficacy similar to that of aspirin for …

… Chemoprevention of colorectal cancer is already possible with … associated with COX-2
inhibitors. Better patient selection and … at moderate to high colorectal cancer risk and low risk of …

… cyclooxygenase-2 inhibitors. A single placebo-controlled randomized trial of aspirin has shown
long-term colorectal cancer … chemopreventive effect of aspirin and other cyclooxygenase …

… (CRC) is the second most frequent deadly cancer in the United State. The proposed …
Etiologically, colon cancer is caused by spread of colorectal cancer cells to other parts of the body. …

… Chemopreventive strategies for colorectal cancer (CRC) have been … )-2 inhibitors have
been proven as promising and the most attractive candidates for CRC clinical chemoprevention. …

… that is associated with an increased risk of colorectal cancer at a … Chemoprevention of
intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor…

… PGI 2 is an alternative approach. In this direction, we have developed LFA9, with dual 5-LOX
and mPGES-1 inhibitor as a safer colon cancer chemopreventive that was observed to be …