[HTML][HTML] Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole

D Frank, L Schenck, A Koynov, Y Su, Y Li… - Pharmaceutics, 2021 - mdpi.com
prepared in a range of solvents. Following the patent literature [43,44], polymorphs of
posaconazole were prepared … that both originate from solvent-induced plasticization of the ASD. In …

Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions

M Sun, C Wu, Q Fu, D Di, X Kuang, C Wang… - International journal of …, 2016 - Elsevier
… In order to assess the polymers’ ability to maintain the supersaturation of lacidipine, a solvent-…
Preparation of amorphous solid dispersions ASDs were prepared by solvent evaporation. …

Solvent-assisted hot melt extrusion of a thermally labile, high melting point compound

C Lagan, JE Huckle, JM Katz, B Khorsand, D Daurio… - AAPS …, 2021 - Springer
… -intensive process, which can become an important deciding factor due to organic solvents
… In this work, a new approach is presented, utilizing HME technology to prepare an ASD of …

The underestimated contribution of the solvent to the phase behavior of highly drug loaded amorphous solid dispersions

S Dedroog, E Boel, C Kindts, B Appeltans… - International Journal of …, 2021 - Elsevier
… in residual solvent of the spray dried ASDs prepared using diverse solvents, for every solvent,
… The identification of additional solvent selection criteria is not only important to choose an …

Ternary solid dispersions: classification and formulation considerations

S Borde, SK Paul, H Chauhan - Drug Development and Industrial …, 2021 - Taylor & Francis
… and in this review, ASD is used in the same manner. … used to prepare ASDs, namely the
melting and solvent evaporation … Selection of preparation method of TSD based on organic …

[HTML][HTML] High drug loading nanosized amorphous solid dispersion (NASD) with enhanced in vitro solubility and permeability: Benchmarking conventional ASD

GP Andrews, K Qian, E Jacobs, DS Jones… - International Journal of …, 2023 - Elsevier
… and NASD formulations via a continuous organic solvent/… The ASD and NASD formulations
were prepared using the 10 … In addition, although the selection of polymer and drug loading …

Highly efficient miniaturized coprecipitation screening (MiCoS) for amorphous solid dispersion formulation development

Q Hu, DS Choi, H Chokshi, N Shah… - International journal of …, 2013 - Elsevier
… The selection of the right polymer and drug loading (DL) are … use volatile solvents and generate
ASD by solvent casting … For example, with MiCoS it is possible to prepare an ASD of BCS …

Amorphous solid dispersion of ibuprofen: A comparative study on the effect of solution based techniques

A Ziaee, S O'Dea, A Howard-Hildige, L Padrela… - International journal of …, 2019 - Elsevier
… the impact of three different solvent-based processing … and dissolution properties of ASD
formulations of Ibuprofen (IBU… were evaluated for the preparation of ASDs of IBU with polymers …

Preparation of amorphous solid dispersions by cryomilling: chemical and physical concerns related to active pharmaceutical ingredients and carriers

T Pas, A Bergonzi, E Michiels, F Rousseau… - Molecular …, 2020 - ACS Publications
… Compared to most conventional ASD-manufacturing techniques (heat- and solvent-based) …
Preparation of Amorphous Solid Dispersions by Cryomilling ASDs were prepared by …

Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations

B Démuth, ZK Nagy, A Balogh, T Vigh, G Marosi… - International journal of …, 2015 - Elsevier
good method to prepare an ASD. Besides choosing the appropriate polymer, selection of
the suitable … technologies in the preparation of ASD due to its scalability, solvent-free feature …