Exploring the feasibility of the use of biopolymers as a carrier in the formulation of amorphous solid dispersions–Part I: Gelatin
T Pas, B Vergauwen, G Van den Mooter - International journal of …, 2018 - Elsevier
… ) suspensions are prepared for subsequent development … polymers, selection of adequate
processing techniques is … In the effort of realizing this, ASD production by a solvent method …
processing techniques is … In the effort of realizing this, ASD production by a solvent method …
A rational approach towards development of amorphous solid dispersions: experimental and computational techniques
P Chakravarty, JW Lubach, J Hau… - International Journal of …, 2017 - Elsevier
… of an ASD based on polymer selection by determining its … was employed to remove the
solvent and obtain the lyophilized … method of preparation affects the performance of ASDs. Thus…
solvent and obtain the lyophilized … method of preparation affects the performance of ASDs. Thus…
Effect of surfactant on the in vitro dissolution and the oral bioavailability of a weakly basic drug from an amorphous solid dispersion
… ASD was optimized by the application of casting film, solvent … The impact of the surfactant
on ASD prepared by the spray-… selection of the optimal approach for this weakly basic drug. …
on ASD prepared by the spray-… selection of the optimal approach for this weakly basic drug. …
Oral formulations for preclinical studies: principle, design, and development considerations
Y Gao, C Gesenberg, W Zheng - Developing solid oral dosage forms, 2017 - Elsevier
… percentage, after which the solubility goes downhill with further increase of the good solvent…
used in ASDs will retain or pick up water during formulation preparation and storage. For …
used in ASDs will retain or pick up water during formulation preparation and storage. For …
Mesoporous ASD: Fundamentals
A Garcia-Bennett, A Feiler - Amorphous Solid Dispersions: Theory and …, 2014 - Springer
… such as SBA-15 (prepared with polymeric surfactants). In these … The commonly used solvent
in laboratory experiments … the loaded particles by choosing a suitable solvent in which the …
in laboratory experiments … the loaded particles by choosing a suitable solvent in which the …
Generality of Enhancing the Dissolution Rates of Free Acid Amorphous Solid Dispersions by the Incorporation of Sodium Hydroxide
HJ Zhang, CW Chiang… - Molecular …, 2024 - ACS Publications
… solvents, rotary evaporation was deemed unsuitable for preparing their ASD samples because
the required solvent … This also highlights the importance of selecting the same solvent …
the required solvent … This also highlights the importance of selecting the same solvent …
[HTML][HTML] ASD formation prior to material characterization as key parameter for accurate measurements and subsequent process simulation for hot-melt extrusion
K Kayser, M Monschke, KG Wagner - AAPS PharmSciTech, 2022 - Springer
… Selection of quasi-adiabatic conditions during early process development in lab scale would
ease the process of scale-up; however, finding the right and … sample preparation methods, …
ease the process of scale-up; however, finding the right and … sample preparation methods, …
Excipients for amorphous solid dispersions
… choosing a polymer for ASD, one has to be careful to select … ASD prepared by solvent
method like SD, the drug is dissolved in a solution of the hydrophilic polymer in an organic solvent. …
method like SD, the drug is dissolved in a solution of the hydrophilic polymer in an organic solvent. …
Investigation into the solid-state properties and dissolution profile of spray-dried ternary amorphous solid dispersions: a rational step toward the design and …
S Baghel, H Cathcart, NJ O'Reilly - Molecular pharmaceutics, 2018 - ACS Publications
… and optimize ternary ASDs. Thus, it would seem that the … 48 h to remove the residual solvent.
In a standard TGA ramp … DVS analysis of freshly prepared DPM ASDs with PVP (a), HPMC (…
In a standard TGA ramp … DVS analysis of freshly prepared DPM ASDs with PVP (a), HPMC (…
Dissolution testing of amorphous solid dispersions
K Kogermann, A Penkina, K Predbannikova… - International journal of …, 2013 - Elsevier
… In the ASDs prepared by solvent evaporation the amorphous API is stabilized by the … solvent
evaporation rate, temperature and moisture may greatly change the characteristics of ASDs (…
evaporation rate, temperature and moisture may greatly change the characteristics of ASDs (…