… evidence for a circadian basis of mood disorders and then … depressive disorders appear
to display abnormal circadian … in circadian clock genes result in a similar manic phenotype. …

… abnormalities induce depression-like behaviour in the tail suspension test [53,54]. Based
on these previous studies, our findings suggest that the negative mood phenotype observed in …

… of bipolar disorder (BD). We focused on circadian rhythm sleep-wake disorders (CRSWD) as
… clinical variables between the patients with bipolar disorder and major depressive disorder. …

… of changes in circadian clocks to the aetiology of mood disorders is only negative, or …
light-associated changes in circadian timing play in the onset of depressive-like behaviour in dLAN, …

… Possible phenotypic differences may offer a challenge for further studies and the development
… This is particularly interesting as bipolar disorder and depression share clinical features, …

… affecting circadian amplitude in young adults with the bipolar … depression are considered
features of a bipolar phenotype. … a sleep phenotype in the development of bipolar disorder and …

… We suggest that the circadian pattern described is amenable to “objective” study using …
value in the study of the chronobiology of pediatric bipolar disorder in its manifold forms. …

… circadian rhythm is a key feature of bipolar disorder. Variation in genes encoding components
of the molecular circadian … Clock mutant mice have a very similar circadian phenotype to …

… in various subtypes of depression [32, 33]. In the case of bipolar disorder, causality appears
… genes with both extreme circadian sleep/wake phenotypes and circadian pathology (Table 2…

… that genetic associations between circadian clock gene variants … disorders such as MDD,
bipolar disorder, schizophrenia and so on, phenotyping the overt manifestations of the disorder …