… Herein we report on an extensive comparative study of the EGFR inhibitors regarding
their proton dissociation processes, fluorescence properties and their HSA binding affinities …

… acute-phase protein human serum albumin (HSA, 600 M) is … ing to the ATP-binding pocket
of the EGFR/HER2 protein … Upon comparison with the reported binding data of marketed …

… kinase inhibitor of the EGFR and was approved by the FDA in … apoptosis in EGFR-overexpressing
human tumor cells [153-… inhibition of the intracellular domain through the ATP binding …

… This drug was approved by the US FDA in May 2003. GEF … In comparison with the results
for either GEF or REG alone, … Thus, in this study, the interaction between EGFR inhibitor (…

… Binding towards human serum albumin (HSA) and α1-acid … comparative study of three
approved FGFR inhibitors and … and their HSA and AGP binding affinities investigated by means of …

… that bind covalently to albumin as well as physically binding … sugar moieties bound to human
serum albumin are not described … These data warranted a phase III study in comparison to …

… epidermal growth factor receptor (EGFR) exon 21 (L858R) … the binding of the various drugs
to BSA and serum albumins, … Comparing the quenching effect of AFB on the fluorescence …

… factor receptor (EGFR) by inhibiting their phosphorylation [5], [6… A comparison of the differences
in the fluorescence intensity … for further clinical research and novel drug delivery systems. …

… 1) is FDA approved multi-targeted oral drug, which … epidermal growth factor receptor (EGFR)
tyrosine kinase, that are … Bar diagram showing comparison of thermal stability of HSA in the …

… From the Clinical Editor … In this study we investigated the specific binding and accumulation
of cetuximab… expression was higher in comparison with LS174T cells with low EGFR …