Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches

M Selman, VJ Thannickal, A Pardo, DA Zisman… - Drugs, 2004 - Springer
… alveolar inflammation eventuating in fibrosis and destruction of the lung architecture. Anti-inflammatory
therapies employing corticosteroids or immunosuppressive or cytotoxic agents …

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

P Spagnolo, R Tonelli, AV Samarelli… - Expert Opinion on …, 2022 - Taylor & Francis
… that modulate the inflammatory response, such as steroids, … they modulate inflammation by
secreting a multitude of cytokines … ; indeed, IFN-γ is a pro-inflammatory cytokine and a potent …

[HTML][HTML] Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis

M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu… - … cell research & therapy, 2016 - Springer
… -inflammatory/fibrotic cytokines, including IL-6, IFN-γ, TNFα, … -ILD patients who had not
received corticosteroid therapy (n = … To investigate the role of human MSCs in the modulation of …

Current and future therapeutic approaches in idiopathic pulmonary fibrosis

D Bouros, KM Antoniou - European Respiratory Journal, 2005 - Eur Respiratory Soc
IFN-γ is an inflammatory cytokine with a number of inhibitory … better response to
immunosuppressive and corticosteroid therapy, it … Cytoskeletal protein modulation in pulmonary

Treatment of idiopathic pulmonary fibrosis

CE Daniels, JH Ryu - … in Respiratory and Critical Care …, 2006 - thieme-connect.com
… Gamma interferon (IFN-γ) is an endogenous cytokine with … [51] Specifically, IFN-γ modulates
the T(H)1/T(H)2 response, … Fortunately, we will learn more about the role of IFN-γ through an …

[HTML][HTML] Growth factors in idiopathic pulmonary fibrosis: relative roles

JT Allen, MA Spiteri - Respiratory research, 2001 - Springer
… , in which the roles of "various cytokines and growth factors" are … A preliminary trial of IFN-γ
co-therapy in IPF patients led to … modulation in pulmonary alveolar myo-fibroblasts during …

[HTML][HTML] Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis

EH Alhamad, JG Cal, Z Shakoor, A Almogren… - BMC medical …, 2013 - Springer
IL-6, IL-10, interferon gamma (IFN-γ), TNF-α, and TGF-β 1 … None of the patients was
receiving any corticosteroids or … IFN-γ is a Th-1 cytokine that plays pivotal roles in modulating

Idiopathic pulmonary fibrosis: treatment options in pursuit of evidence-based approaches

G Raghu - European Respiratory Journal, 2006 - Eur Respiratory Soc
… survival favouring the treatment with IFN-γ-1b over colchicine … , newer treatment strategies
to modulate the fibrotic response … of the cytokine/chemokine cocktail in pulmonary fibrosis: how …

Pharmacotherapy in patients with idiopathic pulmonary fibrosis

S Nagai, T Handa, DS Kim - Expert Opinion on Pharmacotherapy, 2008 - Taylor & Francis
… another immunosuppressive agent showed better pulmonary … Th2 cytokines predominantly
and IFN-γ may modulate the Th1/… study of IFN-γ plus prednisolone for the treatment of IPF, …

Emerging drugs for idiopathic pulmonary fibrosis

M Selman, A Pardo, L Richeldi… - Expert opinion on …, 2011 - Taylor & Francis
… , corticosteroids have been the initial mainstay of treatment, … IFN-γ is an endogenously
cytokine with antifibrotic, anti-infective, … any further use of IFN-γ 1b alone in the treatment of IPF. …