… DNA and host defenses is well-studied, the role of cytoDNA in aging and chronic diseases
… : micronuclei, cytoplasmic chromatin fragments, mitochondrial DNA, and retrotransposons. …

… Several cytosolic DNA sensors have been identified including … Following binding to cytosolic
DNA, these sensors activate … strictly age-related diseases, they demonstrate that cytosolic …

… Finally, we posit that various sources of DNA (extracellular … in human aging and age-related
diseases was predicted at … the cytoplasmic DNA sensor cGAS and the endosomal DNA …

… dichotomous roles of cytoplasmic DNA-sensing pathways in pulmonary inflammatory disease
… suggests that the accumulated cytoplasmic DNA in aged CD4 + T-cells sensed by the KU …

… , we hypothesized that cytosolic DNA would be more … aging disease cells, we did not
conclusively show that DNA levels … the sources of excess DNA and damaged DNA in …

… sources for ROS in the cell is oxidative phosphorylation within mitochondria, so that the
free-radical theory of aging is essentially a mitochondrial theory of aging. … in nutrient sensing and …

… The accumulation of DNA in the cytoplasm can initiate the … Moreover, cytosolic DNA sensing
is intimately connected to … the molecular mechanisms whereby cytosolic DNA enables cell-…

… Both endogenous processes and exogenous physical and chemical sources generate
deoxyribonucleic acid (DNA) damage in the nucleus and organelles of living cells. To prevent …

… Although aging and aging-related diseases are initiated or … DNA that can form in the D-loop
can be the source of DNA … it more immunostimulant for cytosolic sensor NLRP3. The NLRP3 …

… Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor … and prokaryotes suggests that
DNA sensing is an evolutionarily … This DNA can be derived from multiple sources, including …