… genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine–pyrimethamine …
…, M Bakary, J Le Bras, P Deloron - Journal of …, 2003 - academic.oup.com
… in this article are part of a treatment efficacy study that compared the sulfadoxine–pyrimethamine
(SP) … Unfortunately, our isolates did not include a genotype mutant at both 436 and 437 …
(SP) … Unfortunately, our isolates did not include a genotype mutant at both 436 and 437 …
[HTML][HTML] High prevalence of genotypes associated with sulfadoxine/pyrimethamine resistance in the rural area of Fougamou, Gabon
FM Boukoumba, JB Lekana-Douki, PB Matsiegui… - Journal of Global …, 2021 - Elsevier
… Plasmodium falciparum dihydropteroate synthase (Pfdhps) and … Clinical trials to investigate
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …
the efficacy of IPT-SP are much … Pyrimethamine binds far more strongly to the parasite DHFR …
[HTML][HTML] Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal
D Ndiaye, B Dieye, YD Ndiaye, D Van Tyne… - International Journal for …, 2013 - Elsevier
… be incorporated with ongoing in vivo efficacy monitoring in areas … falciparum isolates
from Thies, as the increase in the number … Dhfr and dhps genotype and sulfadoxine–pyrimethamine …
from Thies, as the increase in the number … Dhfr and dhps genotype and sulfadoxine–pyrimethamine …
[HTML][HTML] High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children
G Mombo-Ngoma, S Oyakhirome, R Ord, JJ Gabor… - Malaria Journal, 2011 - Springer
… -108, which is associated with cycloguanil resistance [28–30]. … of SP treatment efficacy in
Gabon. These findings suggest … Treatment during infancy with sulfadoxine-pyrimethamine (…
Gabon. These findings suggest … Treatment during infancy with sulfadoxine-pyrimethamine (…
Molecular analysis of DHFR and DHPS genes in P. falciparum clinical isolates from the Haut–Ogooué region in Gabon
DP Mawili-Mboumba, MT Ekala, F Lekoulou, F Ntoumi - Acta tropica, 2001 - Elsevier
… falciparum genotype was present in 64% of the samples. We … in the DHFR gene, and have
been associated with in vitro … to P/S in these Gabonese areas where a low efficacy of P/S was …
been associated with in vitro … to P/S in these Gabonese areas where a low efficacy of P/S was …
[PDF][PDF] Polymorphisms in pfcrt, pfmdr1, dhfr genes and in vitro responses to antimalarials in Plasmodium falciparum isolates from Bangui, Central African Republic
D Menard, F Yapou, A Manirakiza… - … American journal of …, 2006 - publicationslist.org
… genotype and chemosensitivity to pyrimethamine. For the … associated with sulfadoxine-pyrimethamine
(SP) treatment failure … vitro susceptibility of Gabonese wild isolates of Plasmodium …
(SP) treatment failure … vitro susceptibility of Gabonese wild isolates of Plasmodium …
… of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in …
B Bwijo, A Kaneko, M Takechi, IL Zungu, Y Moriyama… - Acta tropica, 2003 - Elsevier
… and sulfadoxine/pyrimethamine activity against parasite … To evaluate SP efficacy seven
years after Malawi replaced … between pyrimethamine and cycloguanil activity in vitro and …
years after Malawi replaced … between pyrimethamine and cycloguanil activity in vitro and …
… alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon
MK Bouyou-Akotet, DP Mawili-Mboumba… - Journal of …, 2010 - academic.oup.com
… DHFR and DHPS genotypes of Plasmodium falciparum … of pyrimethamine and
cycloguanil, but not with sulfadoxine–pyrimethamine treatment efficacy …
cycloguanil, but not with sulfadoxine–pyrimethamine treatment efficacy …
[HTML][HTML] Seasonal Malaria Chemoprevention with Sulphadoxine-Pyrimethamine and Amodiaquine Selects Pfdhfr-dhps Quintuple Mutant Genotype in Mali
H Maiga, E Lasry, M Diarra, I Sagara, A Bamadio… - PLoS …, 2016 - journals.plos.org
… falciparum dihydrofolate reductase [Pfdhfr], respectively [5]. … resistance are widespread, SP
plus AQ remain efficacious in … preventive treatment [IPTi] with SP alone in infants in Gabon, …
plus AQ remain efficacious in … preventive treatment [IPTi] with SP alone in infants in Gabon, …
Frequencies of dhfr/dhps multiple mutations and Plasmodium falciparum submicroscopic gametocyte carriage in Gabonese pregnant women following IPTp-SP …
MK Bouyou-Akotet, ML Tshibola… - Acta Parasitologica, 2015 - Springer
… intermittent preventive treatment with sulfadoxine-pyrimethamine (… the partial efficacy of
two SP doses to clear these isolates. A … to pyrimethamine in Plasmodium falciparum malaria …
two SP doses to clear these isolates. A … to pyrimethamine in Plasmodium falciparum malaria …