… Although the molecular details of the interactions of [PtCl 2 (E-iminoether) 2 ] complexes
with DNA described in this section are not fully understood, the information obtained from the …

… Summary: The B→Z transition of DNA modified by platinum(II) complexes has attracted
considerable interest because of a possible relationship with the molecular mechanism of …

… reveal potential differences in conformational alterations imposed on DNA by these two
adducts. … For instance, antitumor trans ‐[PtCl 2 (NH 3 )(thiazole)] forms on DNA monofunctional …

… antitumor trans-EE modifies DNA in a different way than “classical” cisplatin which forms on
DNA … Anyway, more detailed information about cellular processing of DNA modified by trans-…

… ), while for the ethoxy analogue the two configurations (E or Z) … to answer two key questions:
Is cellular DNA a cytotoxic target … of DNA modification by trans[PtCl2{E-HN=C(OEt)Me}2] (1) …

… of trans-[PtCl 2 (NH 3 )(thiazole)] and trans-[PtCl 2 (thiazole) 2 ] … charge transfer induced DNA
photobinding in a Ru(II)–Pt(II) … therapeutic window: a new mechanism for DNA modification …

… modifications of DNA by antitumor trans-[PtCl2(NH3)(quinoline)]. The results indicated that
trans-[PtCl2… that in this particutions by antitumor trans-[PtCl2(E-iminoether)2], Mol. Pharmacol. …

… but recognizes antibodies raised to trans-DDP-modified DNA [… PtCl 2 (E-iminoether) 2 ] The
prevalent lesion occurring in double-stranded DNA modified by trans-[PtCl 2 (E-iminoether) 2 …

… The antitumor trans-platinum complexes, whose DNA-binding mode will be reviewed in
this section, include three distinct series (Fig. 15): (i) analogs containing planar amine ligand, …

… (E-iminoether) 2 ] can persist considerably longer than the … Thus, trans-[PtCl 2 (E-iminoether)
2 ] represents a quite new … adducts of antitumor trans-platinum compounds modify the DNA …