… In this study, we explored the role of oral tolerance and … of IgA nephropathy (IgAN), an
important form of nephritis in … sion of oral tolerance, which otherwise develops after chronic oral …

… on the experimental system, however, oral tolerance can be … of mucosal tolerance apparently
exerts a nephritogenic effect by … Nephritis does not develop in complement-deficient mice …

… These experiments show that defective oral tolerance, by permitting persistence ofIgG …
promotes nephritis, complement-fixing IgG and IgM co-deposits are critical for nephritogenesis in …

… the formation of potentially nephritogenic immune complexes … that the process of oral tolerance
occurs in healthy humans (… in the hematuria of experimental IgA nephropathy. Lab Invest …

… unwitting “experiments” in which cadaveric kidneys with mesangial IgA deposits were … a
defective clearance by this route, although it is still possible that a small pool of nephritogenic …

… -deficient O-glycans in its hinge region (galactose-deficient IgA1… This scenario is further
supported by the results of experiments … that are responsible for promoting the migration of these …

… the role that defective clearance plays in IgA nephritogenesis have not … Defective oral
tolerance promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization…

… GESUALDO L, LAMM ME, EMANCIPATOR SN: Defective oral tolerance promotes
nephritogenesis in experimental IgA nephropathy induced by oral immunization. J Immunol 145:3684…

… in the generation of nephritogenic IgA, formation of IgA-IC and their … Defective oral tolerance
promotes nephritogenesis in experimental IgA nephropathy induced by oral immunization…

… in people without significant glycosylation defects, as long as … model of gluten-induced
experimental IgA glomerulopathy. … B cells are involved in nephritogenic IgA synthesis in a T-cell-…