… To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming oligonucleotides …

… topoisomerase I-mediated DNA cleavage in cells. In the first part of our study, we showed
that these optimized conjugates … sequence-specific DNA cleavage near the triplex site (Citation…

… Topoisomerase I (topo I) is a ubiquitous DNA-cleaving enzyme and an important … optimized
TFO−CPT conjugates not only induce strong and highly sequence-specific DNA cleavage but …

… We have shown that the novel sequence-specific camptothecins … induce a targeted DNA
cleavage mediated by topoisomerase I with … by triple helix-forming oligonucleotide conjugates. A …

… Triple helix‐forming oligonucleotides covalently linked to … Sequence‐specific DNA cleavage
by topoisomerase I occurs … for the DNA/Topo I/TFO conjugate complex, optimizing the length …

… camptothecins as well as for indolocarbazole antibiotics such as rebeccamycin. To achieve
a sequence-specific cleavage of DNA by topoisomerase I, … conjugate with an optimized linker …

… sequence-specific recognition properties of TFOs can be exploited to direct DNA cleaving
and alkylating agents to chosen DNA … camptothecin, a topoisomerase I poison, for which the …

… to perform a sequence-specific DNA modification (eg, DNA cleavage). … of sequence-specific
DNA ligands: triple helix-forming … shown that the conjugation of a camptothecin derivative to …

… sequence-specific topo II-mediated DNA cleavage. The 5′ … In conclusion, the use of triple
helix-forming ODNs to target … camptothecin-triple helix forming oligonucleotide conjugate …

… -stranded DNA cleavage and new DNA-cleaving agents and … Sequence-specific DNA
cleavage using topoisomerase I … conjugated of triple helix-forming oligonucleotides. Bioorgan …