… and distant organ interactions that can lead to multi-organ failure. Moreover, the severity of
organ dysfunction … organ dysfunction (eg, acute respiratory distress syndrome [ARDS], cardiac …

… distant organ dysfunction. There is a higher chance of distant organ dysfunction with more
severe … severe enough to require renal replacement therapy can also experience multiorgan …

… kidney dysfunction contribute to poor prognosis. These findings support the premise that
AKI-induced distant organ dysfunction … AKI induces injury and dysfunction in distant organs, …

… Despite the availability of renal replacement therapy, acute kidney injury (AKI) is associated
… In animal models, however, it is increasingly clear that AKI induces distant organ dysfunction…

… distant-organ dysfunction includes evidence that inflammatory cascades are abnormal after
organ injury… -channel expression in distant organs are deranged after kidney injury. The …

… Dialysis-requiring AKI is a severe condition with an unacceptably high mortality rate of 40% …
% with associated distant organ dysfunction states such as cardiac and respiratory failure.7, …

… organ dysfunction is associated with a high death rate. We propose that persistent organ
dysfunction … (2) systemic inflammation as a consequence of kidney injury (3) treatment-related …

… Acute kidney injury leads to distant organ injury through a … Acute kidney injury leads to distant
organ injury through a … Serum and distal organ cytokine levels increase in conjunction with …

… from extra-renal manifestations of organ dysfunction and as … in organ cross talk and distant
organ damage secondary to … in mediating systemic and remote organ effects following AKI is …

… While cytokines/chemokines, leukocyte extravasation, oxidative stress, and certain channel
dysregulation are the pathways involving in the remote organ damage. In the current review, …