… allows other proteins to both induce and repress protein … protein kinase (MAPK), p38, the
protein kinase C alpha (PKC… The aim of this work is to critically review the HuR modulators …

… activity, and a number of kinases have been found to phosphorylate … Chk2 and protein
kinase C delta (Table 1). Besides … Notably, BRCA1 gene mutations comprise the most important …

… by different signalling pathways provides routes to functional … after activation of PKC (protein
kinase C) with bryostatin and … 221 is mutated to a phosphomimetic aspartate residue, HuR …

… work is the first to demonstrate a role for the RNA binding … on non-treated plates to allow
the fibroblasts to adhere. The non-… While our results suggests that PKC does not mediate HuR …

… As PKC-δ and IKKβ-induced phosphorylation of TTP can … by protein kinase A (PKA) and
glycogen synthase kinase 3 … alterations in HuR translocation and ARE mRNA binding affinity are …

… the HuR-LTα mRNA interaction by different RNA binding … cut psiCHECK2 vector, thereby
allowing a forced insertion at the 3… Importantly, luciferase activity was significantly lower in HuR …

… survival activity, elevations in total and/or cytoplasmic HuR levels … protein kinase C (PKC)
inhibitor, the checkpoint kinase 2 … , we compared the RNA binding affinity of recombinant HuR …

… efforts to dissect the different states of the kinase-substrate … catalytic states of the PKC-substrate
interaction. Specifically, … Hence, a phosphomimetic version of peptide number 14 was …

… to be major players in gene regulation that enable local functions, … HuR binds only to the
long, not the short, CD47 3′-UTR. … a 1,000-fold increase in RNA binding affinity. Thus, this and …

… HuR is best known as a direct target of protein kinase C (PKC) … We examined PKC activity
using a PKC activity kit. In this … + -dependent PKC makes a major contribution to PKC activation …