… to confirm ERCC3 as a cancer susceptibility gene for breast cancer and … risk of carriers
for BC and OC, among other tumours. Our data also indicate a putative modifier role of ERCC3 …

… only one ERCC3 mutation (0.11%; OR = 0,2; 95%CI 0,0–1,7). To further delineate the prevalence
of germline ERCC3 mutations in Czech cancer … data from cancer predisposition testing …

… expect to find this gene mutated in high-risk families with a high cancer family history burden…
identified in another cancer risk gene. Hence, five out of 13 ERCC3 Spanish carriers were …

… Overall, our findings reveal a new mechanism of platinum sensitivity in EOC that, unlike
defective HR, may lead to a discordance in sensitivity to platinum and PARPi, with potential …

… of many new genes involved in the predisposition to breast and/or ovarian cancer, with different
… identified as high penetrance genes for the risk of breast/ovarian cancers. Besides them, …

… helicases encoded by ERCC2, ERCC3, and ERCC6 (2, 13). The present study examines
relative mRNA levels of expression of ERCC1 and XPAC in ovarian cancer tissues. We also …

… In this paper, we review candidates for genetic markers of treatment outcomes in ovarian
cancer. Although an association between SNPs and response to chemotherapy has been …

… High grade serous ovarian cancer is (HGSOC) treated by up front cytoreduction surgery …
In HGS ovarian cancer, HR deficiency as a result of BRCA mutations, results in increased …

… XPB (ERCC3), key players in the NER pathway, tend to be higher in OCCC as compared to
other types of ovarian cancers (… a new paradigm for utilizing PI3K inhibitors in ovarian cancer …

… new cases of ovarian cancer diagnosed, leading to 14,000 deaths.1 Primary treatment for
newly diagnosed ovarian cancer is … NER pathway in both ovarian cancer risk and response to …