Effect of genipin on the biliary excretion of cholephilic compounds in rats

M Mikami, H Takikawa - Hepatology Research, 2008 - Wiley Online Library
… choleresis by increasing the biliary excretion of glutathione, which … effect of colchicine on
the choleretic effect of genipin was investigated. The effect of genipin on the biliary excretion

Effect of penicillin G on the biliary excretion of cholephilic compounds in rats

M Fukami, A Tanka, H Takikawa - Journal of hepato-biliary-pancreatic …, 2011 - Springer
Cholephilic compounds are excreted into bile by distinct ATP-… Biliary excretion of organic
anions is mediated by the … that genipin increased bile flow and biliary glutathione excretion [10], …

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers

K Okada, J Shoda, M Kano, S Suzuki… - American Journal …, 2007 - journals.physiology.org
… Administration of ICKT or genipin to rats for 7 days increased bile flow and biliary excretion
… Cholestasis leads to hepatic and systemic accumulation of potentially toxic biliary compounds

[PDF][PDF] Acute and subacute hepatotoxicity of genipin in mice and its potential mechanism

S Wang, S Ge, Y Chen, F Zhou, J Wang, L Chen… - Heliyon, 2023 - cell.com
genipin (GP) limits its application. The aim of this study was to evaluate 18 the acute and
subacute hepatotoxicity of genipin in normal mice and mice … is an iridoid compound and is the …

[HTML][HTML] Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

E Dolezelova, A Prasnicka, J Cermanova… - World Journal of …, 2017 - ncbi.nlm.nih.gov
… resveratrol to increase bile flow in healthy rats by increasing the biliary excretion of bile acids
and … , an enzyme that is crucial for bile acid synthesis. Resveratrol simultaneously induced …

… Pharmacodynamic Interactions between Simvastatin and Gardeniae Fructus in Healthy and High-fat High-cholesterol Diet Induced Nonalcoholic Steatohepatitis Rats

Z Li - 2020 - search.proquest.com
… Fructus induced hepatotoxicity in healthy rats, their co-… relate to the aggravated formation of
the genipin-protein adduct, … and genipin standard solution (0.01 mg/mL of both compounds) …

[PDF][PDF] Geniposide Isolated from Gardeniae Fructus Induces Time-Dependent Hepatic Injury in Mice

JW Zhang, HF Chen, BM Xu, JJ Huang… - Biomedical Journal of …, 2019 - academia.edu
Effect of geniposide and genipin on the biliary excretion, the gastric juice secretion, and
the gastric contraction, and other pharmacological actions (author’s transl). Yakugaku Zasshi …

Phloracetophenone-induced choleresis in rats is mediated through Mrp2

L Tradtrantip, P Piyachaturawat… - American Journal …, 2007 - journals.physiology.org
… , genipin, an intestinal bacterial metabolite of geniposide which is the major active compound
effect of the herbal compound THA in an isolated rat liver perfusion system. THA stimulates …

Mrp2 is involved in benzylpenicillin-induced choleresis

K Ito, T Koresawa, K Nakano… - American Journal of …, 2004 - journals.physiology.org
… A percentage of the [ 3 H]PCG was excreted into the bile of the rats within 60 min (SD rats:
31.7… As a result, we initially demonstrated that a compound that stimulates GSH efflux in vitro …

Effect of epigallocatechin gallate on bile production

P Hiršová - 2013 - dspace.cuni.cz
… Being an aqueous solution, bile is more suitable for excretion of hydrophilic compounds. … ,
is excreted into bile via MRP2/Mrp2 in humans and rodents (Fig. 7). The critical role of Mrp2 in …