… in prostatic intraepithelial neoplasia (PIN) and prostate cancer, … of these data for prostate
cancer chemoprevention. … prospective, randomised, double-blind, placebo-controlled trial [38…

… high-grade prostate intraepithelial neoplasia predict cancer in men who … Chemoprevention
for prostatic carcinoma: the role of flutamide in patients with prostatic intraepithelial neoplasia…

… 46 Similarly, a prospective, placebo-controlled study of TRAMP … 101 There is also evidence
that cessation of flutamide resulted in … endpoints for cancer chemoprevention trials. J. Cell. …

… the first large, randomized, placebo-controlled trial of maximal … and with flutamide in the
treatment of advanced prostate cancer. … Brawer MK: Prostatic intraepithelial neoplasia: a premahg…

… to about 20 years for prostatic intraepithelial neoplasia (PIN). … ever randomized, double-blind,
placebo-controlled study of … dose flutamide anti-androgen therapy on the development of …

… in men with an estimated 241 740 men diagnosed in the … endpoint in chemoprevention
studies of prostate cancer. … -deprivation drugs such as flutamide and bicalutamide 169–…

… rates for most forms of epithelial cancer have not declined in the … at the receptor level, such
as flutamide (18). Unfortunately, … , placebo-controlled, prospective study with cancer as an …

… , randomized, placebo-controlled trial to test this hypothesis. The NCI is sponsoring this trial,
which will enroll 18,000 men. … being tested in two large NCI chemoprevention trials. As these …

… PCa (21 for 5αR2), 18 prostatic intraepithelial neoplasia (PIN), 12 … in chemoprevention of
PCa in high-risk men diagnosed with PIN [… this study was a randomized, placebo-controlled trial …

… from a clinical trial in participants (n = 447) randomized to the … from high-grade prostatic
intraepithelial neoplasia to PCa by … α activity with treatment of flutamide or tamoxifen individually, …