… Erythroid differentiation is highly regulated at the level of mRNA transcription, and factors
controlling the expression of numerous erythroid … of transcripts that change during GATA-1–…

… or erythroleukemia cells and summary of the frequencies of rescue of erythroid differentiation
of GATA-1- ES cells or lacZ expression in … Is GATA- 1 necessary for globin gene switching? …

… have provided strong evidence that GATA-1 is involved in control of globin gene expression
during erythroid differentiation. Targeted mutagenesis of the GATA-1 gene in embryonic …

… , is a major epigenetic change during erythroid development and is associated with a
reduction of active enhancers and super-enhancers (SEs) upon differentiation; (2) promoters are …

… of enhancer usage during HSPC to erythroid differentiation revealed switches at ∼30% of
… GATA switches involve replacement of one GATA factor by another at a chromatin target site…

… during erythroid differentiation, 17,18 as … at distinct sites within erythroid cells and
megakaryocytes, we suspected that different cofactors would be responsible for recruiting GATA …

… , whereas GATA-1 drives the differentiation of hematopoietic … GATA-1 expression, GATA-1
displaces GATA-2 (GATA switch… the GATA switch is depicted to occur in the erythroid lineage, …

… change in the majority of the cell population, these results indicate a downregulation of GATA-
1 expression when … Because GATA- 1 is necessary for terminal erythroid differentiation, its …

… -2 and GATA-1 … During GATA factor switch, the GATA-1 expression will increase due to
the reciprocal decrease of GATA-2, which leads progenitor cells to adopt an erythroid lineage. …

… plausible that CBP induces a conformational change involving these regions. In addition, it
cannot be ruled out that other important factors interact with GATA-1 outside the finger region. …