… -epigenome signalling pathway, the glucose–AMPK–TET2–5hmC axis, which links the level
… ultimately, diabetes to cancer. We have identified AMPK-mediated TET2 phosphorylation at …

… AMPK; so it is unable to phosphorylate TET2 and TSC1/2 … Hyperglycemia linked diabetes
to cancer via the glucose-AMPK-TET2-… If we alter the biosynthesis of AMPK and TET2 natural …

… the genesis of cancer could be due to the unstable form of the AMPK-TET2 axis under …
Glucoseregulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer…

… A western blot analysis revealed that in both the CRC cell … AMPK modulates TET2 stability
through phosphorylation of … AMPK, has a TET2-dependent anti-tumor effect in diabetic nude …

… AMPK- TET2- 5hmC axis signaling pathway, linking the level of extracellular glucose to the
dynamic epigenetic regulation of 5hmC with implications in diabetes and cancer (… reveal that …

… diseases such as diabetes, obesity, inflammation and cancer [10,… phosphorylated TET2
(Ser97 [m], Ser99 [h]), enzyme-linked … of endogenous TET2 protein revealed that TET2 primarily …

… multivariate analysis revealed that the AMPK high/TET2 low … expression levels of AMPK or
phosphorylated AMPK have been … of AMPK/TET2 expression levels in diabetes mellitus based …

… cancer genes compared with controls (3). The meta-study also revealed that genes encoding
2 epigenetic regulators, TET2 … of the TET2 protein via the AMPK signaling pathway (13). …

… , a kinase that phosphorylates TET2 and prevents it from … have been studied in various
cancers, but its relationship with … needed to reveal how empagliflozin regulates AMPK, whether …

… TET2 is an important link between diabetes and cancer… Glucose-regulated phosphorylation
of TET2 by AMPK reveals a pathway linking diabetes to cancer (13). Metformin is a first-line …