… neurodegenerative disorders share a common epigenomic defect we obtained the complete
human DNA methylomes … base resolution using whole-genome bisulfite sequencing (WGBS…

… neurodegenerative diseases from the epigenetic perspective. … to show a shared non-Mendelian
property between DNA … in methylation patterns during epigenetic reprograming may …

… DNA methylation at CpG sites is an essential epigenetic … stage whereas DNA methylation
showed the reverse pattern. Genes … DNA methylation patterns are modified by environmental …

… Several epigenetic regulatory mechanisms – including DNA methylation, histone post-… ,
and long noncoding RNA – have all been shown to control chromatin structure and regulate a …

… anonymous bands that represent the methylome of the cell. … diseases have an epigenetic
basis or at least an epigenetic … sequence-specific epigenetic patterns and their modification …

… Using a similar concept to genome-wide association studies, methylome… arthritis demonstrate
if differences we find are specific to … We also found a similar distribution pattern of predicted …

… disease (PD) is a multifactorial neurodegenerative disorder … ) would correlate with the brain
methylome. We investigated … independent iterations, showed only n = 6 common probes that …

… of epigenetic dysregulation that have been found in Alzheimer’s and other neurodegenerative
diseases. … These observations demonstrate how a factor linked to ALS can be important in …

… have pointed to the role of epigenetic changes such as DNA … load, diverse epigenetic patterns
are accumulated depending … Postmortem methylome profiling of brains from patients with …

… because these disorders exhibit distinct patterns of neuronal … To explore changes in the
brain methylome in HD individuals… of early cell death in neurodegenerative disorders. Indeed, …